Transfer device for use in mixing a primary solution and a secondary or additive substance

• US 4,296,786 A
• Filed: 09/28/1979
• Issued: 10/27/1981
• Est. Priority Date: 09/28/1979
• Status: Expired due to Term

• Current Assignee: West Corporation
• Original Assignee: West Corporation
• Inventors: Brignola, Dominic J.
• Primary Examiner(s): Marmor, Charles A.
• Application Number:
  US06/079,867
• Time in Patent Office: 760 Days
• Field of Search: 222/81, 222/83, 222/83.5, 222/85-86, 141/19, 141/329-330, 141/309, 141/319, 137/575, 206/365, 128/272.1, 128/272.3, 128/214.2, 128/221, 215/320, 215/DIG. 3
• US Class Current: 141/309
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2055 having gripping means
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2072 for internal venting
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096

Abstract

A transfer device for use in mixing substances in different containers normally closed by a stopper of resilient material having a puncturable diaphragm consisting of a central body portion and a pair of aligned spikes or cannulas projecting from opposite sides of said central body portion. Each of the cannulas terminates in a tip portion remote from the central body portion and there are at least one pair of transfer passages extending through the cannulas, the opening at one tip portion of one of the transfer passages is of smaller cross section than the opening of said transfer passage at the tip of the other cannula. The other transfer passage is the reverse of the first transfer passage; that is, the cross sectional relationships of the openings at the tips are the opposite of the first transfer passage. Thus in use the cannulas are inserted through the stopper in a pair of containers to transfer contents, usually fluid, from one container to the other, and the specific arrangement of the transfer passages facilitates smooth flow through the transfer device, one being a fluid passage, the other an air venting passage. The invention also includes the combination of a transfer device, an outer cover member including means for supporting the transfer device therein and a detachable closure member overlying and normally sealing the opening in the outer cover member.

Claims

1. A transfer device for use in mixing substances in different containers comprising a central body portion and a pair of cannulas projecting from opposite sides of said central body portion, each of said cannulas having an outer tip portion, means defining at least one pair of transfer passages extending through said cannulas and extending the full length of said cannulas from the tip portion of one cannula to the tip portion of the other cannula, the cross sectional area of one of said transfer passages adjacent the tip of one cannula being greater than the cross sectional area of said one transfer passage adjacent the tip of said other cannula, each of the transfer passages being of circular cross section, one of said transfer passages converging toward the tip of one cannula and the other transfer passage converging toward the tip of the other cannula.

2. A transfer device as claimed in claim 1 wherein the tip of each cannula is tapered in relation to the central axis thereof at an angle of between 45°

and 60°

.

3. A transfer device as claimed in claim 1 wherein the central body portion is of a disc-like configuration.

4. A transfer device as claimed in claim 1 wherein the tip of each cannula is tapered relative to the central axis thereof and the face of the tapered tip is arcuate.

5. A transfer device as claimed in claim 1 wherein the cannulas are coated with a lubricant to facilitate insertion and removal of the stopper.

6. A transfer device as claimed in claim 1 wherein the tip of each cannula is tapered in relation to the central axis thereof, and each tip has a contoured arcuate piercing face.

7. A transfer device as claimed in claim 1 wherein each of said cannulas is of an enlarged cross section adjacent said central body portion to define an annular shoulder on each cannula spaced outwardly from said body portion and inwardly from the tip portion of said cannulas.

8. The combination including a transfer device for use in mixing substances in different containers;

one of said containers having a closure member in the discharge opening therein, said transfer device comprising a central body portion and a pair of aligned cannulas projecting from opposite sides of said central body portion, each terminating at its outer end in a tip portion, means defining at least one transfer passage extending through said cannulas, an outer cover member including means for supporting the transfer device therein in spaced relation from the closure member, said outer cover member having an opening and a detachable closure member overlying said opening, means for supporting said transfer device in said outer cover member comprising at least a pair of diametrically opposed spaced lugs on the interior and having inner face portions cooperable with said central body portion to retain said transfer device in place in the outer cover member, said outer cover member having a lower section and including at least a pair of diametrically opposed detents on the inner wall thereof having axial face portions spaced apart a distance greater than the spacing of said lugs.

9. The combination as claimed in claim 8 wherein said cover member is heat sealed at its outer periphery to an outwardly directed flange adjacent the opening in said outer cover member.

10. The combination as claimed in claim 8 wherein the inner face portion of at least two adjacent lugs taper inwardly at a small angle of approximately 2°

.

11. The combination as claimed in claim 8 wherein one of said containers includes a stopper having a diaphragm and wherein the wall of the stopper below the diaphragm tapers outwardly.

12. The combination as claimed in claim 8 including an overcap assembly consisting of a protective cover secured to said closure member and an auxiliary closure cap mounted in said protective cover member.

13. The combination as claimed in claim 8 wherein said central body portion is of generally circular shape and wherein the confronting face portions of said lugs are spaced apart a distance less than the diameter of said disc portion to provide a friction fit therebetween.

14. The combination including a transfer device for use in mixing substances in different containers comprises a central body portion and a pair of aligned cannulas projecting from opposite sides of-said central body portion, means defining at least one transfer passage extending through said cannulas, an outer cover member including means for supporting the transfer device therein, said outer cover member including means for detachably securing it directly to the container, the portion of the outer cover member above said detachable means being provided with a plurality of axially extending score lines which upon removal of said detachable means and actuation of said cover member relative to said container to insert said transfer device causes separation along said axial score lines.

15. The combination including a transfer device for use in mixing substances in different containers comprising a central body portion and a pair of aligned cannulas projecting from opposite sides of said central body portion, means defining at least one pair of transfer passages extending through said cannulas, one of said transfer passages being of a greater cross sectional area at the tip of one of said cannulas than the cross sectional area of the other transfer passage, said one transfer passage having a smaller cross section than the other transfer passage at the tip of the other cannula, an outer cover member including means for supporting the transfer device therein and means in the form of a detachable tear band for detachably securing said cover member to said container, the portion of said outer cover member above said tear band being provided with a plurality of axially extending score lines which upon removal of the tear band and actuation of said cover member relative to said container to insert said transfer device causes separation along said axial score lines.

16. The combination including a transfer device for use in mixing substances in different containers comprising a central body portion and a pair of aligned cannulas projecting from opposite sides of said central body portion, means defining at least one pair of transfer passages extending through said cannulas, one of said transfer passages being a greater cross sectional area at the tip of one of said cannulas than the cross sectional area of the other transfer passage, said one transfer passage having a smaller cross section than the other transfer passage at the tip of the other cannula, said container having mounted in the opening thereof a puncturable diaphragm and an outer cover member including means for supporting said transfer device so that one of the tip portions overlies the puncturable diaphragm whereby upon actuation of said cover member axially towards said container, said tip portion engages through said diaphragm.

17. The combination including a transfer device for use in mixing substances in different containers comprising a central body portion and a pair of aligned cannulas projecting from opposite sides of said central body portion, means defining at least one transfer passage extending through said cannulas, an outer cover member including means for supporting the transfer device therein and means for detachably securing said cover member to said container, the portion of said outer cover member above said detachable means being provided with a plurality of axially extending score lines which upon removal of the detachable means and actuation of said cover member relative to said container to insert said transfer device causes separation along said axial score lines.

18. The combination including a transfer device for use in mixing substances in different containers comprising a central body portion and a pair of aligned cannulas projecting from opposite sides of said central body portion, means defining at least one pair of transfer passages extending through said cannulas, one of said transfer passages being of a greater cross sectional area at the tip of one of said cannulas than the cross sectional area of the other transfer passages, said one transfer passages having a smaller cross section than the other transfer passage at the tip of the other cannula, an outer cover member including means for supporting the transfer device therein, said outer cover member including means for detachably securing it directly to the container.

19. The combination as claimed in claim 18 wherein said detachable means connecting said outer cover member includes a detachable tear band connected to the housing by a scored area.

20. The combination as claimed in claim 19 wherein the portion of the outer cover member above said tear band is provided with a plurality of axially extending score lines which upon removal of said tear band and actuation of said cover member relative to said container to insert said transfer device causes separation along said axial score lines.

21. The combination including a transfer device for use in mixing substances in different containers comprising a central body portion and a pair of aligned cannulas projecting from opposite sides of said central body portion, means defining at least one pair of transfer passages extending through said cannulas, one of said transfer passages being of a greater cross sectional area at the tip of one of said cannulas than the cross sectional area of the other transfer passages, said one transfer passage having a smaller cross section than the other transfer passage at the tip of the other cannula, an outer cover member including means for supporting the transfer device therein, said outer cover member including means for detachably securing it directly to the container, said detachable means connecting said outer cover member including a detachable tear band connected to the housing by a scored area.

22. A transfer device for use in mixing substances in different containers comprising a central body portion and a pair of cannulas projecting from opposite sides of said central body portion, each of said cannulas having an outer tip portion, means defining at least one pair of transfer passages extending through said cannulas and extending the full length of said cannulas from the tip portion of one cannula to the tip portion of said other cannula, the cross sectional area of one of said transfer passages adjacent the tip of one cannula being greater than the cross sectional area of said one transfer passage adjacent the tip of said other cannula, the cross sectional area of said other transfer passage adjacent the tip of said other cannula being greater than the cross sectional area of said other passage adjacent the tip of said one cannula, the cross sectional area of said one transfer passage adjacent the tip of said one cannula being greater than the cross sectional area of said other transfer passage at the tip of said one cannula and the cross sectional area of said other transfer passage adjacent the tip of said other cannula being greater than the cross sectional area of the one transfer passage adjacent the tip of said other cannula.

23. The combination including a transfer device for use in mixing substances in different containers comprising a body portion and a pair of cannulas projecting from opposite sides of said body portion, means defining at least one transfer passage extending through said cannulas, an outer cover member comprising first and second sections, means detachably securing said first section of said cover member to one of said containers, means releasably connecting said first and second sections, means mounting said transfer device in said second section, a stopper assembly comprising a pierceable diaphragm portion mounted in the discharge opening in said one container one of said cannulas being aligned with said diaphragm, said second section adapted for telescoping actuation relative to said first section upon release of said connecting means whereby said one cannula punctures said diaphragm to establish communication with the interior of the container.

24. The combination as claimed in claim 23 including means for sealing said first section to said one container.

25. The combination as claimed in claim 24 wherein said sealing means comprises a complementary rib and groove means on the first section and said stopper assembly.

26. The combination as claimed in claim 24 wherein said sealing means comprises an O-ring mounted between said first section and said stopper assembly.

27. The combination as claimed in claim 23 wherein said connecting means comprises a fracturable bridge connection.

28. The combination as claimed in claim 23 wherein said connecting means for said sections comprises at least one detent mounted on the interior wall of said first section and a radial lip on the second section engageable with said detent to normally retain said transfer device in an unarmed position, said lip disengageable from said detent to permit telescopic movement of said sections to arm said transfer device.

29. The combination as claimed in claim 23 wherein said stopper includes an elongated sleeve projecting upwardly from stopper snugly embracing one of the cannulas and serving as a guide means therefor.

30. A transfer device for use in mixing substances in different containers comprising a central body portion and a pair of cannulas projecting from opposite sides of said central body portion, each of said cannulas having an outer tip portion, means defining at least one pair of transfer passages extending through said cannulas and extending the full length of said cannulas from the tip portion of one cannula to the tip portion of the other cannula, the cross sectional area of one of said transfer passages adjacent the tip of one cannula being greater than the cross sectional area of said one transfer passage adjacent the tip of said other cannula, one of said transfer passages converging toward the tip of one cannula and the other transfer passage converging toward the tip of the other cannula.

31. A transfer device for use in mixing substances in different containers comprising a central body portion and a pair of cannulas projecting from opposite sides of said central body portion, each of said cannulas having an outer tip portion, means defining at least one pair of transfer passages extending through said cannulas and extending the full length of said cannulas from the tip portion of one cannula to the tip portion of the other cannula, one of said transfer passages being tapered relative to its central axis and converging toward the tip portion of one cannula and the other transfer passage being tapered relative to its central axis and converging toward the tip portion of the other cannula.

32. A transfer device for use in mixing substances in different containers comprising a central body portion and a pair of cannulas projecting from opposite sides of said central body portion, each of said cannulas having an outer tip portion, means defining at least one pair of transfer passages extending through said cannulas and extending the full length of said cannulas from the tip portion of one cannula to the tip portion of the other cannula, each of said passages being of a stepped configuration, one of said transfer passages including a first passageway section extending from the tip of one cannula and being of greater cross section than a second passageway section extending from the tip of the other cannula, the other transfer passage including a third passageway section extending from the tip of one cannula and being of a smaller cross section than a fourth passageway extending from the tip of the other cannula.