Solid-phase immunoassays using magnetic glass
First Claim
1. In a process for carrying out a solid-phase immunoassay wherein a biological material is complexed with a water-insoluble, inert particulate carrier and, during the assay, the particulate carrier is separated from a fluid, the improvement which comprises utilizing, as said particulate carrier, water-insoluble, inert, magnetically-dilute particles of a glass and/or crystal-containing material having iron-containing, magnetic crystals incorporated therein with dimensions of less than about 1000 A which are essentially enveloped within the glass and/or crystal structure, and magnetically separating said particulate carrier from said fluid.
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Accused Products
Abstract
Solid-phase immunoassay procedures employing magnetic glass or crystal-containing material, or a superparamagnetic material formed of magnetic particles dispersed in a non-magnetic matrix, as particulate carrier.
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Citations
34 Claims
- 1. In a process for carrying out a solid-phase immunoassay wherein a biological material is complexed with a water-insoluble, inert particulate carrier and, during the assay, the particulate carrier is separated from a fluid, the improvement which comprises utilizing, as said particulate carrier, water-insoluble, inert, magnetically-dilute particles of a glass and/or crystal-containing material having iron-containing, magnetic crystals incorporated therein with dimensions of less than about 1000 A which are essentially enveloped within the glass and/or crystal structure, and magnetically separating said particulate carrier from said fluid.
- 18. A solid-phase immunoassay reagent consisting essentially of water-soluble, inert, magnetically-dilute carrier particles having biological material carried on the surface thereof, which particles consist essentially of a glass and/or crystal-containing material having iron-containing, magnetic crystals incorporated therein with dimensions of less than about 1000 A which are essentially enveloped within the glass and/or crystal structure.
Specification