Diagnostic evaluation, measurement, and analysis of functional activity in body organs that utilize transmembrane ion polarization and depolarization

• US 4,307,726 A
• Filed: 09/04/1979
• Issued: 12/29/1981
• Est. Priority Date: 04/24/1978
• Status: Expired due to Term

• Current Assignee: James C. Paulson, Robert D. Pfeifer
• Original Assignee: James C. Paulson, Robert D. Pfeifer
• Inventors: Paulson, James C., Pfeifer, Robert D.
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/071,992
• Time in Patent Office: 847 Days
• Field of Search: 128/630, 128/653
• US Class Current: 600/407
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4519 Muscles A61B5/389, A61B5/224 take precedence

Abstract

Beams of coherent microwaves or other frequencies of highly directional electromagnetic radiation are passed through the living human body to detect and provide a quantitative analysis of functional activity in the central nervous system and/or in muscle tissue such as that of the heart. Organs to be analyzed are situated in the space of an electrostatic field of oscillating intensity. The directional beam is passed through a body organ situated in this way. The method is of use in detecting degenerative subcortical disease in the brain (e.g., Sulphatide Lipidosis), tissue damage to nerve fibers due to toxic chemicals, and other types of tissue-based functional abnormality. Functional condition of brain and heart generally can be readily analyzed without exposure to ionizing radiation.

Claims

1. A method of diagnostic radiological analysis of a body part comprising the steps of:

(a) producing a coherent directional beam of electromagnetic radiation;

(b) locating the body part to be studied between two chargeable plates;

(c) producing an electrostatic field between said plates and adjusting the intensity and frequency of variation or oscillation of intensity of said field;

(d) propagating said beam through said body part; and

(e) producing an image of the received beam.

2. The method of claim 1 wherein the step of producing a beam comprises generating a beam of microwave frequency using a MASER.

3. The method of claim 1 wherein said body part comprises the human brain and said step of producing an image comprises forming an image of ionic dipole density variations within the human head, and which further compares regional abnormalities to images of space occupying lesions and other abnormalities of body part tissue density variation.

4. The method of claim 1 wherein said body part comprises the human heart and which further comprises the step of forming an image of ionic dipole density variations within the heart and detecting localized abnormalities evidenced in said image.

5. The method of claim 1 which further comprises scanning said directional beam through said body part.

6. The method of claim 5 in which said scanning step is performed by sequentially producing a plurality of said beams from discrete locations around an arc having a focus at said body part.

7. Apparatus for diagnostic analysis of a body part comprising:

generating means for a coherent directional beam of electromagnetic radiation,

a pair of parallel metallic plates spaced apart to receive said body part,

means for producing an oscillating electrostatic field between said plates and for adjusting the intensity and frequency of variation or oscillation of intensity of said field,

a transducer for receiving said beam after it has passed between said plates and said body part, and means for producing an image of the beam received by said transducer.

8. Apparatus according to claim 7 which further comprises means for deflecting said beam whereby to scan at least a portion of said body part.

9. Apparatus according to claim 8 in which said lastmentioned means is a ferro-electric beam deflector.

10. Apparatus according to claim 8 in which said means for producing an image comprises first detector means receiving signals both from said generating means and said transducer and comparing said signals for phase change, second detector means receiving signals both from said means for producing an oscillating field and from said first detector means and filtering out noise from said signals.

11. Apparatus according to claim 7 in which said generating means is of microwave frequency

12. Apparatus according to claim 11 in which said generating means ia a MASER.

13. Apparatus according to claim 10 which further comprises a plurality of said generating means spaced apart and all directing their beams to pass between said plates, and timing means for sequentially activating each said generating means, said means for deflecting said beam controlling all of said generating means.

14. Apparatus according to claim 7 which further comprises a first analog to digital converter receiving a signal from said second detector means, a second analog to digital converter receiving signals from both said timing means and said means for deflecting said beam and emitting a signal indicative of which of said beam generators is activated, a digital computer comparing the outputs of both said analog to digital converters to locate coordinate positions corresponding to the scaler magnitude output from said first analog to digital converter, a digital to analog converter receiving the output of said computer and means for displaying the output of said last-mentioned converter.

15. Apparatus according to claim 14 which further comprises a recorder for the output of said last-mentioned converter.