Intravascular implantation device and method of using the same

• US 4,309,776 A
• Filed: 05/13/1980
• Issued: 01/12/1982
• Est. Priority Date: 05/13/1980
• Status: Expired due to Term

• Current Assignee: Ramon Berguer
• Original Assignee: Ramon Berguer
• Inventors: Berguer, Ramon
• Primary Examiner(s): FRINKS, RONALD
• Application Number:
  US06/149,484
• Time in Patent Office: 609 Days
• Field of Search: 3/1, 3/1.4, 128/260, 128/1 R, 128/DIG. 14
• US Class Current: 623/1.41
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

An intravascular device having a chamber for containing transplanted cells. The device is adapted to be implanted in a wall of a blood vessel with a porous chamber-forming wall of the chamber providing an interface between the cells in the chamber and the blood in the vessel. The chamber-forming wall has a pore size permitting continuous diffusion of hormonal components therethrough but blocking the diffusion of cells. The device may also be implanted between an artery and a vein in a wall of each so as to act as a sieve between the artery and vein subject to the differential pressure therebetween. A method is also disclosed for employing the device to introduce hormonal components into the blood stream.

Claims

1. An intravascular device having a chamber for containing transplanted cells and having outwardly extending peripheral flange means designed and shaped for suturing in an opening made in the wall of a blood vessel with a porous chamber-forming wall thereof providing an interface between the cells in the chamber and the blood in the vessel, said porous chamber-forming wall having a pore size permitting continuous diffusion of hormonal components therethrough but blocking the diffusion of cells.

3. An intravascular device as defined in claim 1 or 2, wherein the pores in said chamber-forming wall or walls have a diameter in a range on the order of about 0.2 microns to 25 microns.

4. An intravascular device as defined in claim 1 or 2 wherein said device is made of a biocompatible, non-thrombus-inducing material.

5. An intravascular device as defined in claim 1 or 2, wherein said device is made of polytetrafluoroethylene.

6. An intravascular device as defined in claim 1 or 2, wherein other walls of said device not in contact with the blood will become effectively non-porous once they are healed and thereby block diffusion of cellular and hormonal components.

7. An intravascular device as defined in claim 1, wherein said device is in the form of a considerably flattened and somewhat elongated hollow body, said flange means comprising a peripheral flange on said body about a line of maximum circumference thereof for attachment to a wall of the blood vessel.

9. An intravascular device as defined in claim 1 or 2, including a tube communicating with said chamber for the introduction of hormone-producing cells.

2. An intravascular device having a chamber for containing transplanted cells and adapted to be implanted between an artery and a vein and having outwardly extending peripheral flange means designed and shaped for suturing in an opening made in a wall of each with a porous chamber-forming wall of said device providing an interface between the cells in said chamber and the blood in the artery and another porous chamber-forming wall of said device providing an interface between the cells in said chamber and the blood in the vein, said porous chamber-forming walls each having a pore size permitting continous diffusion of hormonal components therethrough but blocking the diffusion of cells so that said device acts as a sieve between said artery and vein subject to the differential pressure therebetween.

8. An intravascular device as defined in claim 2, wherein said device is in the form of a hollow body, said flange means comprising annular flanges on said body in spaced relation to one another for attachment respectively to a wall of the artery and a wall of the vein.

10. A method for introducing hormonal components into the blood stream comprising implanting in a wall of a blood vessel a device having a chamber containing transplanted cells with a porous chamber-forming wall thereof providing an interface between the cells in the chamber and the blood in the vessel, said porous chamber-forming wall having a pore size permitting continuous diffusion of hormonal components therethrough but blocking the diffusion of cells.

12. A method as defined in claim 10 or 11, wherein the pores in said chamber-forming wall or walls have a diameter in a range on the order of about 0.2 microns to 25 microns.

13. A method as defined in claim 10 or 11, wherein said device is made of a biocompatible, non-thrombus-inducing material.

14. A method as defined in claim 10 or 11, wherein said device is made of polytetrafluoroethylene.

15. A method as defined in claim 10 or 11, wherein other walls of said device not in contact with the blood are effectively non-porous to block diffusion of cellular and hormonal components.

11. A method for introducing hormonal components into the blood stream comprising implanting between an artery and a vein in a wall of each a device having a chamber containing transplanted cells with a porous chamber-forming wall of said device providing an interface between the cells in said chamber and the blood in the artery and another porous chamber-forming wall of said device providing an interface between the cells in said chamber and the blood in the vein, said porous chamber-forming walls each having a pore size permitting continuous diffusion of hormonal components therethrough but blocking the diffusion of cells so that said device acts as a sieve between said artery and vein subject to the differential pressure therebetween.