Liquid transport device containing means for delaying capillary flow

• US 4,310,399 A
• Filed: 12/10/1979
• Issued: 01/12/1982
• Est. Priority Date: 07/23/1979
• Status: Expired due to Term

• Current Assignee: Clinical Diagnostic Systems Inc.
• Original Assignee: Eastman Kodak Company
• Inventors: Columbus, Richard L.
• Primary Examiner(s): Kaplan, G. L.
• Application Number:
  US06/101,662
• Time in Patent Office: 764 Days
• Field of Search: 204/195 R, 204/195 F, 204/195 M, 23/230 R, 422/55-58, 422/98, 422/100
• US Class Current: 204/409
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/087 Multiple sequential chambers
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/0688 surface tension valves, capillary stop, capillary break
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: G01N 27/307 Disposable laminated or multilayered electrodes G01N27/3272 takes precedence

Abstract

A liquid transport device is disclosed for providing capillary flow. The device features a capillary transport zone provided by two opposed surfaces and having at least two regions, and means extending between said regions for delaying flow of liquid therebetween.

Claims

1. In a liquid testing device comprising

(a) two opposing surfaces which are spaced apart a distance effective to induce capillary flow of introduced liquid and to create a void zone of intended liquid transport, said zone comprising at least two distinct regions, at least one of which is a liquid analysis region, and

(b) means permitting introduction of liquid into said zone for capillary transport to said regions,

the improvement comprising gating means located between said two distinct regions for delaying capillary transport of liquid through said zone from one of said regions to other of said regions, said gating means including a gating wall extending across the intended path of liquid flowing from one of said regions to the other so as to delay liquid flow along said path, said wall including a gating aperture therein that is free of fibers.

3. A device as defined in claim 1 or 2, wherein said delaying means retards but does not stop transport of liquid from one of said regions to the other of said regions.

4. A device as defined in claim 1 or 2, wherein said gating means includes two walls, each extending across said transport zone and having a gating aperture therein.

5. A device as defined in claim 4, wherein said permitting means includes two access apertures spaced along the length of said zone, and wherein each of said walls is located in the path of liquid flow between said access apertures.

6. A device as defined in claim 1 or 2, wherein at least one of said opposed surfaces includes, across at least a portion thereof, a plurality of exposed grooves.

2. In a liquid testing device comprising

(a) two opposing surfaces which are spaced apart a distance effective to induce capillary flow of introduced liquid and to create a void zone of intended liquid transport, said zone comprising at least two distinct regions at least one of which is a liquid analysis region,

(b) an ion-selective electrode fluidly connected to said one liquid analysis region, and

(c) means permitting introduction of liquid into said zone for capillary transport to said regions,

the improvement comprising gating means located between said two distinct regions for delaying capillary transport of liquid through said zone from one of said regions to other of said regions.

7. In a liquid transport device for controlled liquid flow, the device including two opposing liquid transport surfaces, means spacing said surfaces apart a distance effective to induce capillary flow of introduced liquid and to define a transport zone, and means permitting introduction of liquids into said zone at two spaced-apart locations;

the improvement comprising;

a pair of gating means disposed to intercept liquid flow in said zone between said locations, each of said gating means including gating aperture means sized to allow liquid flow to continue at a restricted rate.

8. A device as defined in claim 7, wherein each of said gating means comprises a wall integrally extending from a separating said surfaces, positioned adjacent to a respective one of said locations, said wall having a gating aperture therein.

9. A device as defined in claim 7, wherein at least one of said transport surfaces includes, across at least a portion thereof, a plurality of exposed grooves.

10. In a device for determining activity of an ionic analyte of an aqueous solution, said device including a pair of solid electrodes each constructed to develop therein an electric potential that is proportional in magnitude to the amount of analyte activity present in a contacting drop of said solution;

and flow control means for directing liquid flow from a drop of an aqueous solution to at least one of said electrodes, said control means including

(a) a member bridging and contacting said two electrodes and comprising two opposed liquid transport surfaces and means spacing apart said surfaces a distance effective to induce capillary flow of introduced liquid between said surfaces and to form with said surfaces a transport zone having a predetermined width and length, and

(b) means permitting introduction of liquids into said zone at two spaced-apart locations;

the improvement wherein said spacing means includes gating means intermediate said locations and extending between said surfaces across a major portion of said zone, for delaying flow of liquid within said zone between said locations, said gating means including gating aperture means sized to provide restricted liquid flow between said two locations.

11. A device as defined in claim 10, wherein said gating means includes two walls each extending across said transport zone and having a gating aperture therein.

12. A device as defined in claim 11, wherein said permitting means include two access apertures spaced along the length of said zone and extending from an exterior surface of said member inwardly through one of said transport surfaces to said transport zone, and wherein each of said walls is located between said apertures.

13. In a device for determining activity of an ionic analyte of an aqueous solution, said device including a pair of solid electrodes each constructed to develop therein an electrical potential that is proportional in magnitude to the amount of analyte activity present in a contacting drop of said solution;

and flow control means for directing liquid flow from a drop of an aqueous solution to at least one of said electrodes, said control means including

(a) a member bridging said two electrodes and comprising two opposed liquid transport surfaces spaced apart a distance effective to induce capillary flow of introduced liquid between said surfaces and to form with said surfaces a transport zone, and

(b) means permitting introduction of liquids into said zone at two spaced-apart locations;

the improvement comprising;

gating means disposed to intercept liquid flow in said zone between said locations, for delaying liquid flow through said zone, said gating means including gating aperture means sized to allow liquid flow to continue at a restricted rate between said two locations.

14. A device as defined in claim 13, wherein said gating aperture means is directly interposed in the path of liquid flow between said locations.

15. A device as defined in claim 13, wherein at least one of said transport surfaces includes, across at least a portion thereof, a plurality of exposed grooves.

16. In a device for determining activity of an ionic analyte of an aqueous solution, said device including a pair of solid electrodes each constructed to develop therein an electrical potential that is proportional in magnitude to the amount of analyte activity present in a contacting drop of said solution;

and flow control means for directing liquid flow from a drop of an aqueous solution to at least one of said electrodes, said control means including

(a) a member bridging said two electrodes and comprising two opposed liquid transport surfaces spaced apart a distance effective to induce capillary flow of introduced liquid between said surfaces and to form with said surfaces a transport zone, and

(b) means permitting introduction of liquids into said zone at two spaced-apart locations;

the improvement comprising;

a pair of gating means disposed across the path of liquid flow in said zone between said two locations for delaying liquid flow through said zone, each of said gating means including gating aperture means sized to allow liquid flow to continue at a restricted rate between said locations.

17. A device as defined in claim 16, wherein each of said gating means comprises a wall integrally extending from and separating said surfaces and having a gating aperture therein.

18. A device as defined in claim 16, wherein said gating aperture are directly interposed in the path of liquid flow between said locations.

19. A device as defined in claim 16, wherein at least one of said transport surfaces includes, across at least a portion thereof, a plurality of exposed grooves.