Pressure-sensitive adhesive having a broad spectrum antimicrobial therein

• US 4,310,509 A
• Filed: 07/31/1979
• Issued: 01/12/1982
• Est. Priority Date: 07/31/1979
• Status: Expired due to Term

• Current Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Rosso, Paul D., Berglund, Claire A.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/062,363
• Time in Patent Office: 896 Days
• Field of Search: 424/28, 424/80, 424/81, 424/150, 128/155, 128/156, 128/268
• US Class Current: 424/448
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/12 Iodine, e.g. iodophors; Compounds thereof
• CPC Class Codes: A61F 2013/0071 containing active agent
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 2300/202 with halogen atoms, e.g. triclosan, povidone-iodine
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents

Abstract

A composition and a process for making the same is provided wherein a chemical and storage stable pressure-sensitive adhesive has homogeneously dispersed therein a broad-spectrum antimicrobial agent. When the composition is placed in contact with the skin, it uniformly and controllably releases the broad-spectrum antimicrobial agent with substantially unaltered broad-spectrum antimicrobial activity.

Claims

1. A process for making a dermatologically acceptable composition which controllably releases an antiseptically active broad-spectrum antimicrobial agent when placed in contact with skin comprising forming a solution of a broad-spectrum antimicrobial agent;

forming a room temperature tacky pressure-sensitive adhesive which is compatible with said broad-spectrum antimicrobial agent;

mixing said antimicrobial agent solution and said pressure-sensitive adhesive such that the broad-spectrum antimicrobial agent from said antimicrobial agent solution is homogeneously dispersed in said pressure-sensitive adhesive; and

drying said homogeneous dispersion so as to remove said solvents leaving an antiseptically active amount of said broad-spectrum antimicrobial agent homogeneously and stably dispersed in said pressure-sensitive adhesive.

2. The process of claim 1 which includes the additional step of introducing a surfactant into said antimicrobial agent solution prior to mixing with said pressure-sensitive adhesive.

3. A composition which releases an antiseptically active broad-spectrum antimicrobial when placed in contact with skin comprising an antiseptically active amount of a broad-spectrum antimicrobial agent and a dermatologically acceptable room temperature tacky pressure-sensitive adhesive which is chemically compatible with said broad-spectrum antimicrobial, said broad-spectrum antimicrobial agent being homogeneously and stably dispersed in said pressure-sensitive adhesive.

4. The composition of claim 3 wherein said antiseptically active broad-spectrum antimicrobial agent is chlorhexidine.

5. The composition of claim 3 wherein said antiseptically active broad-spectrum antimicrobial agent is polyvinylpyrrolidone-iodine complex.

6. A flexible backing material having attached thereto a composition which releases an antiseptically active broad-spectrum antimicrobial agent when placed in contact with skin comprising an antiseptically active amount of a broad-spectrum antimicrobial agent and a dermatologically acceptable room temperature tacky pressure-sensitive adhesive which is chemically compatible with said broad-spectrum antimicrobial agent, said antimicrobial agent being homogenously and stably dispersed in said pressure-sensitive adhesive.

7. The flexible backing material of claim 6 wherein said antiseptically active broad-spectrum antimicrobial agent is chlorhexidine.

8. The flexible backing material of claim 6 wherein said antiseptically active broad-spectrum antimicrobial agent is polyvinylpyrrolidone-iodine complex.

9. The flexible backing material and composition of claim 6 in the form of a drape.

10. The flexible backing material and composition of claim 6 in the form of a tape.

11. The flexible backing material and composition of claim 6 in the form of a dressing.