Selenium derivatives of thyroxine and tri-iodothyronine
First Claim
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1. Selenium derivatives of thyroxine and tri-iodothyronine having the formula:
- ##STR3## wherein either(a)R1 is OHR2 is --CO--CX1 X2 X3,at least one of X1, X2 and X3 is --Ap (SeQ)q,A is saturated alkylene of 1 of 4 carbon atoms,Q is alkyl or alkenyl of 1 to 6 carbon atoms, cycloalkyl, aryl or aralkyl,p is 0 or 1,q is 1 or 2,one of X1, X2 and X3 may be amino andany other of X1, X2 or X3 is H, andM is H or I;
or(b)R2 is H,R1 is --NZ--CY1 Y2 Y3,at least one of Y1, Y2 and Y3 is --A--(SeQ)q,one of Y1, Y2 and Y3 may be --COR4 where R4 is OH,any other of Y1, Y2 and Y3 may be H,Z is H or --A--(SeQ)q,A is saturated alkylene of 1 to 4 carbon atoms,Q is alkyl or alkenyl or 1 to 6 carbon atoms,cycloalkyl, aryl or aralkyl,q is 1 or 2, andM is H or I.
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Abstract
Novel Selenium derivatives of thyroxine and tri-iodothyronine have the formula: ##STR1## wherein M is I or H and either (a) R1 is OH or a carboxyl protecting group and R2 contains at least one Se, preferably 75 Se, atom or (b) R2 is H or an amino protecting group and R1 contains at least one Se, preferably 75 Se, atom.
The compounds are useful in dual isotope assays of thyroid function.
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Citations
4 Claims
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1. Selenium derivatives of thyroxine and tri-iodothyronine having the formula:
- ##STR3## wherein either
(a) R1 is OH R2 is --CO--CX1 X2 X3, at least one of X1, X2 and X3 is --Ap (SeQ)q, A is saturated alkylene of 1 of 4 carbon atoms, Q is alkyl or alkenyl of 1 to 6 carbon atoms, cycloalkyl, aryl or aralkyl, p is 0 or 1, q is 1 or 2, one of X1, X2 and X3 may be amino and any other of X1, X2 or X3 is H, and M is H or I;
or(b) R2 is H, R1 is --NZ--CY1 Y2 Y3, at least one of Y1, Y2 and Y3 is --A--(SeQ)q, one of Y1, Y2 and Y3 may be --COR4 where R4 is OH, any other of Y1, Y2 and Y3 may be H, Z is H or --A--(SeQ)q, A is saturated alkylene of 1 to 4 carbon atoms, Q is alkyl or alkenyl or 1 to 6 carbon atoms, cycloalkyl, aryl or aralkyl, q is 1 or 2, and M is H or I. - View Dependent Claims (2, 3, 4)
- ##STR3## wherein either
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Current AssigneeAmerlite Diagnostics Limited
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Original AssigneeThe Radiochemical Centre Limited (General Electric Company)
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InventorsCree, Gavin M.
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Primary Examiner(s)Demers, Arthur P.
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Application NumberUS06/116,777Time in Patent Office720 DaysField of Search560/40, 560/37, 560/39, 562/447, 260/558 P, 260/558 R, 260/562 P, 260/562 A, 564/165US Class Current562/447CPC Class CodesC07C 391/00 Compounds containing seleniumY02P 20/55 Design of synthesis routes,...
