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Selenium derivatives of thyroxine and tri-iodothyronine

  • US 4,311,853 A
  • Filed: 01/30/1980
  • Issued: 01/19/1982
  • Est. Priority Date: 02/06/1979
  • Status: Expired due to Term
First Claim
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1. Selenium derivatives of thyroxine and tri-iodothyronine having the formula:

  • ##STR3## wherein either(a)R1 is OHR2 is --CO--CX1 X2 X3,at least one of X1, X2 and X3 is --Ap (SeQ)q,A is saturated alkylene of 1 of 4 carbon atoms,Q is alkyl or alkenyl of 1 to 6 carbon atoms, cycloalkyl, aryl or aralkyl,p is 0 or 1,q is 1 or 2,one of X1, X2 and X3 may be amino andany other of X1, X2 or X3 is H, andM is H or I;

    or(b)R2 is H,R1 is --NZ--CY1 Y2 Y3,at least one of Y1, Y2 and Y3 is --A--(SeQ)q,one of Y1, Y2 and Y3 may be --COR4 where R4 is OH,any other of Y1, Y2 and Y3 may be H,Z is H or --A--(SeQ)q,A is saturated alkylene of 1 to 4 carbon atoms,Q is alkyl or alkenyl or 1 to 6 carbon atoms,cycloalkyl, aryl or aralkyl,q is 1 or 2, andM is H or I.

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