Diagnostic agent for the detection of component materials in liquid and process for producing same

• US 4,312,834 A
• Filed: 02/28/1980
• Issued: 01/26/1982
• Est. Priority Date: 03/15/1979
• Status: Expired due to Term

• Current Assignee: Boehringer Mannheim GmbH (Roche Holding AG)
• Original Assignee: Boehringer Mannheim GmbH (Roche Holding AG)
• Inventors: Werner, Wolfgang, Braun, Hans-Peter, Vogel, Peter, Berger, Dieter
• Primary Examiner(s): Turk, Arnold
• Application Number:
  US06/125,382
• Time in Patent Office: 698 Days
• Field of Search: 23/230 B, 23/931, 23/913, 23/932, 422/56-58, 428/325, 428/328, 428/333, 428/342, 435/805, 435/4, 435/11, 252/408
• US Class Current: 436/66
• CPC Class Codes: G01N 31/22 using chemical indicators G01N31/02 takes precedence
• CPC Class Codes: G01N 33/52 Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements immunological elements G01N33/54386; involving labelled immunochemicals G01N33/58; for haemoglobin or occult blood G01N33/72
• CPC Class Codes: Y10S 435/805 Test papers
• CPC Class Codes: Y10T 436/173076 Nitrite or nitrate

Abstract

Diagnostic agent for the detection of component materials, in liquids and method of production. The diagnostic agent includes a water resistant film composed of a film-former and contains a film opener in the form of fine, insoluble inorganic or organic particles.

Claims

1. Diagnostic agent for the detection of component materials in liquids, comprising a water resistant film comprising a film-former and containing a film opener in the form of fine, insoluble inorganic or organic particles, and the reagents for said detection, wherein the ratio of film opener to film former is 20:

1 to 0.5;

1 by weight.

2. Diagnostic agent as claimed in claim 1 wherein the ratio of film opener to film former is 5:

1 to 1;

1 by weight.

3. Diagnostic agent as claimed in claim 1 for the detection of materials with a low to medium molecular weight, wherein the ratio of film opener to film former is 0.5:

1 to 2;

1 by weight.

4. Diagnostic agent as claimed in claim 1 wherein said water resistant film is fixed to a carrier.

5. Diagnostic agent as claimed in claim 1 for the detection of high molecular weight and corpuscular materials, wherein the ratio of film opener to film former is 1:

1 to 20;

1 by weight.

6. Diagnostic agent as claimed in claim 5 wherein the ratio of film opener to film former is 2:

1 to 5;

1 by weight.

7. Process for the production of a diagnostic agent for the detection of component materials in liquids, the diagnostic agent having a water resistant film composed of a film-former and containing a film opener in the form of fine, insoluble inorganic or organic particles, and the reagents for said detection, which process comprises

mixing the reagents for said detection, and optionally adjuvants, with a solution or dispersion of a film former in liquid medium and the film opener, the film former and film opener being added in an amount to result in a ratio of film opener to film former of 20:

1 to 0.5;

1 by weight,

applying said mixture to a substrate to form a thin film thereon, and

evaporating the liquid therefrom to result in an impregnated substrate.

8. Process as claimed in claim 7 wherein said film is removed from said substrate and is fixed to a carrier.

9. Process for the production of a diagnostic agent for the detection of component materials in liquids, the diagnostic agent having a water resistant film composed of a film-former and containing a film opener in the form of fine, insoluble inorganic or organic particles, and the reagents for said detection, which process comprises

mixing a solution or dispersion of a film former in liquid medium with a film opener in an amount to form a ratio of film opener to film former of 20:

1 to 0.5;

1 by weight,

applying said mixture to a substrate to form a thin film thereon,

evaporating the liquid from said film, and thereafter

applying to said film the reagents for said detection and optionally adjuvants, to result in an impregnated substrate.