Automated, spring-powered medicament infusion system

• US 4,313,439 A
• Filed: 03/24/1980
• Issued: 02/02/1982
• Est. Priority Date: 03/24/1980
• Status: Expired due to Term

• Current Assignee: BioTex Incorporated
• Original Assignee: BioTex Incorporated
• Inventors: Babb, Albert L., Parks, Richard E.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US06/133,320
• Time in Patent Office: 680 Days
• Field of Search: 128/218 R, 128/218 A, 128/218 C, 128/213 R, 128/214 R, 128/214 F, 128/214 E, 128/DIG. 1, 128/DIG. 12, 128/234, 128/224
• US Class Current: 604/28
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2005/31518 designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
• CPC Class Codes: A61M 5/1454 spring-actuated, e.g. by a clockwork
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

A system is provided for the administration of a medicament, such as insulin, to a patient in small, controlled doses over an extended period in response to a continuously generated force. The force may be maintained continuously on a reservoir of the medicament in intermittent communication with a site in the body of the patient through a flexible and compressible tube. A constrictor about the tube keeps it normally closed except when a separate force is exerted to open the constrictor and permit the medicament to flow through the tube for a predetermined period. Alternatively, the continuously generated force may be applied intermittently to the medicament reservoir through the action of an escapement mechanism.

Claims

1. Apparatus for the transcutaneous infusion of a liquid medicament into a patient in controlled doses over an extended period, comprising a syringe including a plunger, and defining a cylindrical reservoir for said medicament and a discharge aperture;

a conduit from said aperture to a subcutaneous site in said patient;

means for generating a continuous force, and means for intermittently impelling said liquid medicament from said reservoir through said conduit to said subcutaneous site under the influence of said continuous force;

said means for intermittently impelling said liquid medicament through said conduit to said subcutaneous site including an escapement mechanism for transmitting said continuous force intermittently to said plunger; and

said escapement mechanism including an escape wheel having a plurality of projections in the vicinity of its circumference and an anchor capable of oscillation about an axis and having two ends with a pallet at each end thereof, said pallets being disposed in such a manner that each pallet alternately engages and releases each projection with each oscillation of said anchor and permits said escape wheel to rotate intermittently by the circumferential distance between adjacent projections; and

said apparatus including means to transmit said continuous force alternately to said escape wheel and to said plunger during each intermittent rotation of said escape wheel.

2. The apparatus of claim 1 including means to oscillate said anchor in response to an electronic control.

3. The apparatus of claim 2 wherein said electronic control is a timer.

4. The apparatus of claim 2 wherein said electronic control is connected to an insulin demand sensor.

5. The apparatus of claim 2 wherein said means for generating a continuous force comprises a spring in tension and said means to transmit said force to said plunger comprises a plurality of aligned balls within a tube.

6. The apparatus of claim 1 including means connected to said escape wheel to rotate a screw, a rider on said screw adapted to move axially thereon as said screw rotates, and means connecting said rider to said plunger.

7. The apparatus of claim 1 wherein said conduit includes a portion which is also a portion of a second conduit between said subcutaneous site and another liquid reservoir.

8. Apparatus for the transcutaneous infusion of a liquid medicament into a patient in controlled doses over an extended period, comprising a syringe including a plunger, and defining a cylindrical reservoir for said medicament and a discharge aperture;

a conduit from said aperture to a subcutaneous site in said patient;

means for generating a continuous force, and means for intermittently impelling said liquid medicament from said reservoir through said conduit to said subcutaneous site under the influence of said continuous force;

said conduit comprising a flexible and compressible tube and said apparatus also including means for transmitting said continuous force to said plunger;

constrictor means about said flexible tube, said constrictor means having an open position which permits fluid passage through said conduit and a closed position which constricts said conduit transversely and cuts off fluid passage therethrough;

closing means normally urging said constrictor means to its closed position;

opening means to overcome said closing means and move said constrictor means to its open position; and

means to actuate said opening means periodically to permit the doses of said medicament to pass through said conduit to said subcutaneous site.

9. The apparatus of claim 8 wherein said means for generating a continuous force comprises a spring in compression.

10. The apparatus of claim 8 wherein said means for transmitting said force comprises a plurality of balls in alignment within a tube.

11. The apparatus of claim 8 wherein said conduit includes a self-sealing septum at one end of said flexible tube and a hypodermic needle penetrating said septum and providing communication between said aperture and said conduit.

12. Apparatus for the transcutaneous infusion of a liquid medicament into a patient comprising a syringe body which includes an elongated barrel having an open end, a central passageway and a discharge end provided with a discharge aperture therein, a plunger situated within the barrel and defining a medicament reservoir between the discharge end and the plunger, delivery conduit means communicating with said reservoir via said discharge aperture and providing a medicament passageway for medicament delivery to a subcutaneous site in the patient, a force generating means, force application means operably associated with said force generating means for transmitting generated force to the plunger, medicament delivery regulator means operably associated with said plunger for governing plunger movement within the barrel in response to the applied force and including an escapement mechanism for interrupting application of generated force to said plunger, and dispensing control means operably associated with said regulator means.

13. The apparatus in accordance with claim 12 wherein said escapement mechanism is solenoid-actuated.

14. The apparatus in accordance with claim 12 wherein said escapement mechanism is balance wheel-actuated.

15. Method for the transcutaneous infusion of a liquid medicament into a patient in controlled doses over an extended period which comprises maintaining a reservoir of said liquid medicament in communication with a subcutaneous site in the body of said patient through a conduit which includes a flexible and transversely compressible tube having a constrictable passageway therethrough, maintaining a constant impelling force, and intermittently forcing liquid medicament from said reservoir through said conduit to said subcutaneous site in response to said impelling force on said liquid medicament in said reservoir by maintaining a transverse constricting force on said flexible tube to bar passage of said liquid medicament through said passageway and periodically applying a force opposite to said transverse constricting force to overcome said transverse constricting force and thereby open said passageway to the passage of said liquid medicament under the influence of said impelling force;

said constant impelling force being transmitted continuously to said liquid medicament in said reservoir.

16. The method of claim 15 wherein said periodic force is actuated by a timing device.

17. The method of claim 16 wherein said periodic force is additionally actuated by said patient at will.

18. The method of claim 15 wherein said periodic force is actuated by a predetermined medicament demand in the body of said patient.

19. The method of claim 15 wherein said reservoir is a syringe having a plunger and said impelling force is a spring in compression acting on said plunger.

20. The method of claim 19 wherein said impelling force is transmitted to said plunger through a plurality of balls aligned within a tube.

21. Method for the transcutaneous infusion of a liquid medicament into a patient in controlled doses over an extended period which comprises maintaining a reservoir of said liquid medicament in communication with a subcutaneous site in the body of said patient through a conduit, maintaining a constant impelling force, and transmitting said constant impelling force intermittently to said liquid medicament in said reservoir through an escapement mechanism which includes an oscillating anchor and an escape wheel driven to rotate by said constant impelling force by rotating said escape wheel through a predetermined arc at each oscillation of said anchor.

22. The method of claim 21 wherein said anchor is actuated to oscillate by a timing mechanism.

23. The method of claim 22 wherein said anchor is additionally actuated to oscillate by said patient at will.

24. The method of claim 21 wherein said anchor oscillates in harmonic rhythm imparted by a balance wheel.

25. The method of claim 24 wherein the rotation of said escape wheel causes the rotation of a screw and the rotation of said screw causes the movement of said plunger.