Chemotherapeutically active maytansinoids from Trewia nudiflora
First Claim
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1. A substantially pure compound selected from the group consisting of trewiasine, dehydrotrewiasine, and N-demethyltrewiasine, characterized by the formula ##STR6## wherein for trewiasine:
- R1 =--CH(CH3)2, R2 =--CH3, and R3 =--CH3 ;
wherein for dehydrotrewiasine;
R1 = ##STR7## R2 =--CH3, and R3 =--CH3 ; and
wherein for N-demethyltrewiasine;
R1 =--CH(CH3)2, R2 =--CH3, and R3 =--H.
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Abstract
A novel group of maytansinoid compounds has been discovered in the seed tissue of Trewia nudiflora. They are represented by the general formula ##STR1## and are all characterized by a distinguishing methoxy group on the C-15 carbon. These isolates have proven to be effective in causing the remission of one or more types of malignancies.
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Citations
8 Claims
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1. A substantially pure compound selected from the group consisting of trewiasine, dehydrotrewiasine, and N-demethyltrewiasine, characterized by the formula ##STR6## wherein for trewiasine:
- R1 =--CH(CH3)2, R2 =--CH3, and R3 =--CH3 ;
wherein for dehydrotrewiasine; R1 = ##STR7## R2 =--CH3, and R3 =--CH3 ; and
wherein for N-demethyltrewiasine;R1 =--CH(CH3)2, R2 =--CH3, and R3 =--H. - View Dependent Claims (2, 3, 4)
- R1 =--CH(CH3)2, R2 =--CH3, and R3 =--CH3 ;
- 5. A chemotherapeutic composition suitable for the remission of leukemia comprising a pharmaceutically acceptable vehicle and an amount effective to promote said remission of a substantially pure compound selected from the group consisting of trewiasine, dehydrotrewiasine, and N-demethyltrewiasine.
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Current AssigneeUnited States Department Of Agriculture
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Original AssigneeUnited States Department Of Agriculture
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InventorsPowell, Richard G., Smith, Cecil R. Jr.
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Primary Examiner(s)BOND, ROBERT
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Application NumberUS06/228,853Time in Patent Office371 DaysField of Search260/239.3 P, 424/248.54US Class Current514/229.5CPC Class CodesC07D 498/18 Bridged systems
