Method and apparatus for selective cell destruction

• US 4,315,514 A
• Filed: 05/08/1980
• Issued: 02/16/1982
• Est. Priority Date: 05/08/1980
• Status: Expired due to Term

• Current Assignee: William Drewes
• Original Assignee: William Drewes
• Inventors: Drewes, William, Levine, Martin
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/148,058
• Time in Patent Office: 649 Days
• Field of Search: 128/660-663, 128/24 A, 128/653, 73/579, 73/601-602
• US Class Current: 600/427
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: A61F 7/00 Heating or cooling appliances for medical or therapeutic treatment of the human body heating or cooling means in connection with bedsteads or mattresses A47C21/00 ; massage, therapeutic baths A61H; hyperthermia using electric or magnetic fields or ultrasound A61N; electric heating elements H05B
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Method for destroying selected cells in a host without damage to non-selected cells comprises selecting a transmission path from an energy source (12) to the selected cells (30); determining one or more of the resonant frequencies of the selected cells (30); selecting as a destructive frequency one of the resonant frequencies at which the transmissibility of the selected cells (30) is higher than the transmissibility of the non-selected cells in the transmission path; and transmitting energy from the source (12) at the destructive frequency along the path with sufficient intensity to destroy the selected cells (30) without destroying the non-selected cells. Apparatus for practicing the method is also disclosed.

Claims

1. A method for destroying selected cells in a host without damage to non-selected cells, comprising:

selecting a transmission path from an energy source to the selected cells;

determining one or more of the resonant frequencies of the selected cells;

comparing the transmissibility of the selected cells at said one or more resonant frequencies with the transmissibility of the non-selected cells in the transmission path at said one or more resonant frequencies;

selecting, as a destructive frequency, one of said one or more resonant frequencies at which the transmissibility of said selected cells is higher than the transmissibility of said non-selected cells in the transmission path; and

transmitting energy from said source at said destructive frequency along said transmission path with sufficient intensity to destroy said selected cells without destroying said non-selected cells in the transmission path.

2. The method according to claim 1, wherein said resonant frequency determining step comprises impacting a biopsy of said selected cells with energy over a predetermined frequency range corresponding to the expected range of said one or more resonant frequencies;

and

detecting the movement of said selected cells during said impacting.

3. The method according to claim 1, wherein said destructive frequency selecting step comprises:

determining the damping coefficients of said selected cells at said one or more resonant frequencies whereby the transmissibility of said selected cells at said one or more resonant frequencies may be determined; and

determining the resonant frequencies and corresponding damping coefficients of said non-selected cells in said transmission path whereby the transmissibility of said non-selected cells at said one or more resonant frequencies may be determined.

4. The method according to claim 1, wherein said energy transmitting step further comprises disposing a coupling medium between said energy source and said host.

5. The method according to claim 1, wherein said energy transmitting step further comprises moving said energy source relative to said host for varying the impact site of said transmitted energy.

6. The method according to claim 1, wherein said energy transmitting step includes the step of determining the transmission losses resulting from transmission of said energy through said path.