Flow rate measurement

• US 4,316,391 A
• Filed: 11/13/1979
• Issued: 02/23/1982
• Est. Priority Date: 11/13/1979
• Status: Expired due to Term

• Current Assignee: Schering Ag (Merck & Co., Inc.)
• Original Assignee: Ultra-Mek Incorporated
• Inventors: Tickner, Ernest G.
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/093,525
• Time in Patent Office: 833 Days
• Field of Search: 128/662, 128/663, 73/19, 73/23, 73/861.06, 73/25-26, 73/861.41
• US Class Current: 73/861.25
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: G01F 1/66 by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters
• CPC Class Codes: G01F 1/704 using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter G01F1/76, G01F25/00 take precedence

Abstract

A method is presented for measuring fluid flow rate in a system having a conduit through which the fluid flows. The method is particularly useful for measuring blood flow rate in a cardiovascular system. A substance which provides a plurality of microbubbles is added to the fluid flow system upstream of the measurement position in the conduit. An ultrasonic pulse is generated from a position opposite and spaced from the conduit as the microbubbles pass therethrough. A reflected ultrasonic image, created by reflection of the pulse from at least the wall of the conduit which is distal from said position, is measured. The fluid flow rate within the conduit is determined from these ultrasonic images using dye dilution techniques. In a living being, the pulse is preferably generated adjacent the rib cage or in the esophagus and the conduit is preferably the heart or the pulmonary artery, whereby, the blood flow rate determined is equal to the volumetric cardiac output rate.

Claims

1. A method of measuring fluid flow rate in a system having a conduit through which fluid flows, comprising:

adding a substance which provides a plurality of bubbles of known size to said system upstream of said conduit;

impelling a sonic pulse across said conduit, from a position opposite and spaced from said conduit, as said bubbles pass therethrough;

measuring the degree of attenuation of a sonic signal defined by said pulse which passes across said conduit, said attenuation being due to the presence of said bubbles; and

determining the fluid flow rate from the degree of attenuation of said sonic signal.

2. A method as in claim 1, wherein said measuring step includes measuring a reflected sonic signal created by reflection of said pulse from a wall of said conduit proximal to said position.

3. A method as in claim 2, wherein said determining step includes determining a ratio of the intensities of those portions of the signal reflected from the proximal and distal walls, and determining bubble density in said conduit from said ratio.

4. A method as in claim 1, wherein said system is a cardiovascular system of a living being, said bubbles are microbubbles, said sonic signal is an ultrasonic signal and said fluid is blood.

5. A method as in claim 4, wherein said position whereat said pulse is generated is a respective one of adjacent a rib cage and within an esophagus of said living being, said conduit is a respective one of a heart and a pulmonary artery, and said blood flow rate is the volumetric cardiac output rate.

6. A method as in claim 4, wherein said measuring step includes measuring a reflected sonic signal created by reflection of said pulse from a wall of said conduit proximal to said position and wherein said determining step includes determining a ratio of the intensities of those portions of the signal reflected from the proximal and distal walls and determining microbubble density in said conduit from said ratio.

7. A method as in claim 1, wherein said adding is of a bolus of said bubbles.

8. A method as in claim 1, wherein said adding is during a selected time period.

9. A method as in claim 1, wherein said degree of attenuation measured is that of a selected portion only of said sonic signal.