Gravitational flow system for the sequential administration of medical liquids

• US 4,316,460 A
• Filed: 07/14/1980
• Issued: 02/23/1982
• Est. Priority Date: 02/28/1979
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Genese, Joseph N., Muetterties, Andrew J.
• Primary Examiner(s): Yasko, John D.
• Application Number:
  US06/167,948
• Time in Patent Office: 589 Days
• Field of Search: 128/214 R, 128/214 C, 128/214 G, 128/227
• US Class Current: 604/31
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/36 with means for eliminating or preventing injection or infusion of air into body dialysis systems, blood oxygenators A61M1/14; haemofiltration equipment A61M1/34; automatic tube cut-off A61M39/281
• CPC Class Codes: B01D 19/0031 by filtration

Abstract

A gravitational flow system for the sequential administration of medical liquids to a patient comprises a primary container connected to a primary tube, a secondary container connected to a secondary tube, and a combined air barrier and liquid sequencing valve which connects them and is in fluid communication with a common tube extending to the patient. A primary flow control device is positioned in the primary flow path and a secondary flow control device is positioned in the secondary flow path. In operation the system dispenses primary liquid unless interrupted by a flow of secondary liquid. In that instance, primary liquid flow is cut off by an air capturing pocket. At the same time, a plurality of air barriers prevent infusion of air into the patient.

Claims

1. A gravitational flow system for the sequential administration of medical liquids to a patient comprising:

a primary container suspended in space for containing a primary medical liquid,

a primary tube having its distal end in fluid communication with said primary container,

a secondary container suspended in space at a height greater than that of said primary container for containing a secondary medical liquid,

a secondary tube having its distal end in fluid communication with said secondary container,

a common tube having its distal end in fluid communication with the proximal ends of said primary and secondary tubes and its proximal end open for the flow of liquid therethrough to form a primary liquid path comprising said primary tube and said common tube and a secondary liquid flow path comprising said secondary tube and said common tube,

secondary flow control means in said secondary liquid flow path for adjusting the flow rate of said secondary liquid therethrough,

primary flow control means on said primary tube for adjusting the flow of said primary liquid through said primary liquid flow path at a rate independent of the flow rate of said secondary liquid through said secondary liquid flow path, and

a combined air barrier and liquid sequencing valve interposed in said primary and secondary flow paths which allows primary liquid to flow from said primary container whenever the height of said primary liquid is less than or equal to the height of said secondary liquid in said system and which prevents primary liquid from flowing from said primary container whenever the height of said primary liquid is less than the height of said secondary liquid in said system,

said combined air barrier and liquid sequencing valve comprising a housing having an air capturing pocket disposed in the primary liquid flow path through said valve, said air capturing pocket being constructed and arranged for the entrapment of a quantity of air therein during dispensing of secondary liquid whereby the flow of primary liquid is halted.

2. The system defined in claim 1, wherein said housing includes a plurality of partition members disposed substantially horizontally within said housing so as to divide said housing into first and second chambers and to seal said first chamber from said second chamber, said partition member including an outlet port incorporated therein, said outlet port being sealed by a hydrophilic membrane for preventing the movement of air between said first and second chambers, said second chamber further including an inlet port for secondary liquid and a plurality of outlet ports at the bottom thereof for the passage of primary and secondary liquid therefrom.

3. The system defined in claim 2 wherein said air capturing pocket comprises a raised platform portion incorporated in said partition member, and an outlet port incorporated in said raised platform portion whereby air may be entrapped within said raised platform portion during dispensing of secondary liquid.

4. The system defined in claim 2 wherein said air capturing pocket comprises a partition disposed downwardly from said horizontal partition member proximate said outlet incorporated therein whereby air may be entrapped below said outlet port during dispensing of secondary liquid so as to halt the flow of primary liquid.

5. The system defined in claim 1 further including a reservoir incorporated therein, said reservoir including a flexible diaphragm disposed across and selectively sealing same, said flexible diaphragm being constructed and arranged for displacement by said secondary liquid, whereby said secondary liquid may pass into said reservoir and through an outlet port positioned proximate the bottom thereof.

6. The system defined in claim 2, wherein said inlet port to said first chamber is positioned proximate the top thereof and said inlet and outlet ports to said second chamber are respectively positioned proximate the side and bottom thereof.

7. The system defined in claim 5, wherein said reservoir is integrally formed as a portion of said second chamber.

8. The system defined in claim 1 or 2, wherein said first chamber further includes a closable air vent.

9. The system defined in claim 8, wherein said air vent is covered by a hydrdophobic membrane.

10. A gravitational flow system for the sequential administration of medical liquids to a patient, comprising:

a primary container suspended in space for containing a primary medical liquid,

a primary tube having its distal end in fluid communication with said primary container for the flow of primary liquid therethrough,

a secondary container suspended in space at a height greater than that of said primary container for containing a secondary medical liquid,

a secondary tube having its distal end in fluid communication with said secondary container for the flow of a secondary medical liquid therethrough,

a common tube having its distal end in fluid communication with the proximal ends of said primary and secondary tubes and its proximal end open for the flow of liquid therethrough to form a primary liquid path comprising said primary tube and said common tube and a secondary liquid flow path comprising said secondary tube and said common tube,

a secondary flow control means in said secondary liquid flow path for adjusting the flow rate of said secondary liquid therethrough,

a primary flow control means on said primary tube for adjusting the flow rate of said primary liquid through said primary flow path to a rate independent of the flow rate of said secondary liquid through said secondary liquid flow path, and

a combined air barrier and liquid sequencing valve having a housing comprising a first chamber which constitutes a portion of said primary tube and has inlet and outlet ports thereto and a second chamber which constitutes a portion of said secondary tube and has inlet and outlet ports thereto,

said first chamber having valve means associated therewith which allows liquid to flow from said primary container whenever the height of said primary liquid is greater than or equal to the height of said secondary liquid in said system and which prevents primary liquid from flowing from said primary container whenever the height of said primary liquid is less than the height of said secondary liquid in said system,

said second chamber having means associated therewith substantially impervious to air while said set is in use to prevent the flow of air through said secondary flow path.

11. The system defined in claim 10 wherein said means associated with said second chamber is a hydrophilic membrane covering said outlet therefrom.

13. The combined air barrier and liquid sequencing valve defined in claim 10 or 12 in which said second chamber further includes a reservoir incorporated therein, said reservoir including a flexible diaphragm member disposed across and selectively sealing one end thereof, and an outlet port in fluid communication with one of said outlet ports from said second chamber for the passage of secondary liquid from said reservoir,

said flexible diaphragm member being constructed and arranged for displacement by secondary liquid in said second chamber so as to allow the passage of secondary liquid through said reservoir and out of said second chamber.

14. The combined air barrier and liquid sequencing valve defined in claim 13 further comprising diaphragm unseating means for the manual displacement of said flexible diaphragm member whereby said second chamber and the secondary liquid flowpath may be primed with liquid prior to use in order to prevent passage of air through the secondary liquid flow path.

15. The combined air barrier and liquid sequencing valve defined in claim 14 wherein said diaphragm unseating means comprises a pin member movably mounted so as to displace said diaphragm as required.

16. The combined air barrier and liquid sequencing valve defined in claim 15 wherein said pin member includes a threaded portion rotatably mounted within said housing whereby the force required to displace said flexible diaphragm member may be adjusted as required.

17. The combined air barrier and liquid sequencing valve defined in claim 10 or 12 in which said inlet port to said first chamber is proximate the top of said housing and includes a passageway to the bottom of said housing in fluid communication with said first chamber;

said outlet port from said first chamber to said second chamber is proximate the top of said first and second chamber;

said air capturing pocket being disposed in said second chamber proximate said outlet port; and

said inlet port to said second chamber includes a passageway which enters said second chamber at a point below said air capturing pocket, so as to entrap air therein by means of the entrance of said secondary liquid.

18. The combined air barrier and liquid sequencing valve defined in claim 10 or 12 wherein said first chamber further includes a closable air vent.

19. The combined air barrier and liquid sequencing valve defined in claim 18 wherein said air vent is positioned proximate the top of said housing and is covered by a hydrophobic membrane thereby preventing the passage of liquid therefrom.

12. A combined air barrier and liquid sequencing valve for the sequential administration of a primary liquid and a secondary liquid comprising:

a housing divided into two or more chambers by a plurality of partition members, a first chamber in said housing having an inlet port incorporated therein for the passage of primary liquid into said first chamber, and an outlet port incorporated therein for the passage of said primary liquid from said first chamber into the second chamber, said outlet port from said first chamber including a hydrophilic membrane incorporated therein and covered thereby for the prevention of air movement between said first chamber and said second chamber when said hydrophilic membrane is moistened,

an inlet port to said second chamber for the admission of secondary liquid and a plurality of outlet ports from said second chamber for the passage of primary or secondary liquid, and

an air capturing pocket proximate said hydrophilic membrane covering said outlet port from said first chamber to said second chamber, said air capturing pocket being constructed and arranged for the reception of residual air within said second chamber proximate said hydrophilic membrane when said secondary liquid is dispensed into said second chamber whereby the flow of said primary liquid is interrupted for so long as the pressure of said secondary liquid is greater than that of said primary liquid.

20. The combined air barrier and liquid sequencing valve defined in claim 2 or 12 wherein said partition member is disposed in a substantially vertical orientation with said first and second chambers being disposed substantially coaxially therefrom.

21. The combined air barrier and liquid sequencing valve defined in claim 20 further including a reservoir incorporated therin for the reception of secondary liquid within said second chamber, said reservoir being constructed and arranged so as to overflow said secondary liquid into said first chamber thereby filling said first chamber and entrapping residual air within said air capturing pocket.

22. The invention according to claim 21 wherein said reservoir is disposed substantially perpendicularly to said diaphragm member.