Osmotically driven fluid dispenser
First Claim
1. In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, shape-retaining membrane encapsulating the layer of osmotically effective solute composition, said membrane being at least in part permeable to water, and a port that extends from the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement wherein the layer of the osmotically effective solute composition is in the form of a thermoformed sleeve consisting essentially of a dispersion of about 50% to about 90% by weight osmotically effective solute, in about 10% to about 50% by weight water soluble thermoplastic polymer vehicle.
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Abstract
An improved version of an osmotically driven mini-osmotic pump that is used to administer drug solutions. The basic components of the improved pump are: an inner flexible bag that holds the drug solution; a plug having a recessed inner end that seals the bag opening; a solution filling/discharge port through the plug; a cup-shaped, thermo-formed sleeve that fits partly about the bag and is made from a dispersion of an osmotically effective solute in a water soluble, theroplastic polymer vehicle; a shape-retaining, semipermeable membrane that encapulates the bag-sleeve subassembly; and a flow moderator that is received through the filling/discharge port in the plug.
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Citations
5 Claims
- 1. In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, shape-retaining membrane encapsulating the layer of osmotically effective solute composition, said membrane being at least in part permeable to water, and a port that extends from the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement wherein the layer of the osmotically effective solute composition is in the form of a thermoformed sleeve consisting essentially of a dispersion of about 50% to about 90% by weight osmotically effective solute, in about 10% to about 50% by weight water soluble thermoplastic polymer vehicle.
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5. In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, shape-retaining membrane encapsulating the layer of osmostically effective solute composition, said membrane being at least in part permeable to water, and a port that extends form the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement wherein the layer of the osmotically effective solute composition is in the form of a thermoformed sleeve consisting of a mixture of 64.5% by weight sodium chloride, 20% by weight poly(ethylene oxide) having a molecular weight of about 600,000, 15% by weight poly(ethylene glycol) having a molecular weight of about 20,000 and 0.5% by weight colloidal silicon dioxide.
Specification