Ionic ophthalmic solutions

• US 4,321,261 A
• Filed: 06/25/1979
• Issued: 03/23/1982
• Est. Priority Date: 01/05/1978
• Status: Expired due to Term

• Current Assignee: B&L International Holdings Corp.
• Original Assignee: Polymer Technology Group, Inc. (DSM-Firmenich AG)
• Inventors: Salamone, Joseph C., Ellis, Edward J.
• Primary Examiner(s): BROWN, JOHNNIE
• Application Number:
  US06/051,961
• Time in Patent Office: 1,002 Days
• Field of Search: 424/180, 424/80, 424/81, 106/16, 106/15 R, 260/29.6 H, 260/29.6 AT, 260/29.6 RW, 260/29.6 WB, 260/29.6 TA, 260/29.6
• US Class Current: 514/57
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61L 12/08 using chemical substances
• CPC Class Codes: B29D 11/00865 Applying coatings; tinting; colouring printing, marking or copying processes B41M; identification in general G09F3/00; producing decorative effects in general B44C; positioning or marking of lenses B24B13/0055
• CPC Class Codes: C08J 2301/28 Alkyl ethers
• CPC Class Codes: C08J 3/03 in aqueous media
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

A contact lens solution is provided for wetting, soaking and lubricating of hard contact lenses, particularly those carrying an ionic charge. The solution contains an ionic polymer of cationic or anionic charge that interacts with an oppositely charged surface of a contact lens forming an interfacial polyelectrolyte complex. This polyelectrolyte complex provides increased, long lasting lens wettability leading to a cushioning and lubricating effect with the eyelid and the cornea.

Claims

1. A lens solution for treating contact lens surfaces to form a protective coating thereon,

said lens solution consisting essentially of a cationic polymer in solution with said polymer being present in an amount of from 0.001 to 10% by weight of said solution,

said solution being useful to form protective coatings on lens surfaces formed of oppositely charged materials by producing a thin coating of a hydrogel when contacted with said contact lens surface,

said lens solution having a pH in the range of 6 to 8.

2. A lens solution in accordance with claim 1 wherein said solution is sterile.

3. A lens solution in accordance with claim 2 wherein said lens solution has a physiologically acceptable pH and is non-irritating to the eye when used as an artificial tear.

4. A lens solution in accordance with claim 2 wherein said cationic polymer is a cellulosic polymer.

8. A lens solution in accordance with claim 1 wherein said solution has the following ingredients:

hydroxyethyl cellulose, benzalkonium chloride, sodium chloride, sodium bi-carbonate, disodium E.D.T.A. and water.

5. A sterile artificial tear solution for treating contact lens surfaces to form a protective coating thereon,

said lens solution having a pH in the range of 6 to 8 and consisting essentially of a cationic cellulosic polymer in aqueous solution with said polymer being present in an amount sufficient to form a thin hydrogel coating on a lens surface of opposite charge.

6. A sterile lens solution for treating contact lens surfaces,

said lens solution consisting essentially of a cationic cellulosic polymer in water solution with said polymer being present in an amount of from 0.001 to 10% by weight of said solution,

said solution being sterile and having a physiologically acceptable pH in the range of 6 to 8.

7. A lens solution in accordance with the lens solution of claim 6 and further comprising lens cleaning and preserving additives.