Neplanocin-B and -F

• US 4,321,376 A
• Filed: 12/07/1979
• Issued: 03/23/1982
• Est. Priority Date: 02/23/1979
• Status: Expired due to Term

• Current Assignee: Asahi Kasei Kogyo Kabushiki Kaisha (Asahi Kasei Corporation)
• Original Assignee: TOYO JOZO Kabushiki Kaisha (Asahi Kasei Corporation)
• Inventors: Saito, Tetsu, Muto, Naoki, Otani, Masaru, Yaginuma, Satoshi, Tsujino, Masatoshi, Fujii, Tadashiro
• Primary Examiner(s): RIZZO, NICHOLAS
• Application Number:
  US06/101,126
• Time in Patent Office: 837 Days
• Field of Search: 544/277, 424/253
• US Class Current: 544/277
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/26 Psychostimulants, e.g. nicotine, cocaine
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 473/00 Heterocyclic compounds containing purine ring systems
• CPC Class Codes: C12N 1/205 Bacterial isolates
• CPC Class Codes: C12P 19/40 having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
• CPC Class Codes: C12R 2001/01 Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Abstract

Neplanocin-B and -F of the formula ##STR1## in which Y is oxygen or a valence bond, are produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin-B and -F thus produced from the culture medium.

Claims

1. Neplanocins of the formula ##STR5## wherein Y is oxygen or a valence bond.

2. Neplanocin B of the formula ##STR6##

3. Neplanocin F of the formula ##STR7##