Vascular prosthesis

• US 4,321,711 A
• Filed: 10/12/1979
• Issued: 03/30/1982
• Est. Priority Date: 10/18/1978
• Status: Expired due to Term

• Current Assignee: Sumitomo Electric Industries Limited (Sumitomo Corporation)
• Original Assignee: Sumitomo Electric Industries Limited (Sumitomo Corporation)
• Inventors: Mano, Hiroshi
• Primary Examiner(s): Crowder, Clifford D.
• Application Number:
  US06/084,323
• Time in Patent Office: 900 Days
• Field of Search: 3/1.4, 3/1
• US Class Current: 623/1.43
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 33/0029 using an intermediate layer of polymer
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene

Abstract

A vascular prosthesis comprising a porous tubing of polytetrafluoroethylene containing an anti-coagulant substance and bonded to its outside surface a porous elastomer coating containing substance which counteracts the anti-coagulant substance is disclosed.

Claims

1. A vascular prosthesis comprising a porous polytetrafluoroethylene tubing having a microstructure composed of fibers and nodes, said nodes being connected to one another by the fibers, said tubing containing an anti-coagulant substance and having a porous elastomer coating bonded to the exterior thereof, said porous elastomer coating containing a substance which counteracts the anti-coagulant substance.

2. The vascular prosthesis of claim 1, wherein said anti-coagulant substance is heparin or its derivative.

3. The vascular prosthesis of claim 2, wherein said haparin or derivatives thereof is contained in said PTFE tubing ionically bonded to a crosslinked polymeric amine.

4. The vascular prosthesis of claim 3, wherein said anti-coagulant is contained in said polymeric gel in an amount of about 0.2 to 5% by weight.

5. The vascular prosthesis of claim 1, wherein said counteracting substance is an inorganic or organic coagulating substance.

6. The vascular prosthesis of claim 1, wherein said counteracting substance is a heparin antagonist.

7. The vascular prosthesis of claim 6, wherein said heparin antagonist is protamine or its derivative.

8. The vasular prosthesis of claim 1, wherein said PTFE tubing has a pore diameter of about 2 to about 100 μ

m, a porosity of at least about 70% and a wall thickness of about 0.3 to 1.0 mm.

9. The vascular prosthesis of claim 8, wherein said porous elastomer coating has an average pore diameter of about 10 μ

m to about 500 μ

m, a thickness of about 20 to about 500 μ

m and a porosity of about 50 to about 95%.

10. The vascular prosthesis of claim 1, wherein said elastomer is selected from the group consisting of fluorine rubber, silicone rubber, urethane rubber, acrylic rubber, and natural rubber.

11. The vascular prosthesis of claim 10, wherein said elastomer has a porosity of about 50% to about 90%.

12. The vascular prosthesis of claim 11, wherein said elastomer coating is about 20 to about 500 μ

m thick.

13. The vascular prosthesis of claim 1, wherein said anti-coagulant is selected from the group consisting of polysaccharide sulfates and organic acids.

14. The vascular prosthesis of claim 13, wherein said anti-coagulant is selected from the group consisting of heparin and derivatives thereof, chondroitin sulfate, charonin sulfate, and citric acid.

15. The vascular prosthesis of claim 1, wherein said anti-coagulant is contained in said PTFE tubing dispersed in a polymeric gel.

16. The vascular prosthesis of claim 1, wherein said substance which counteracts the anti-coagulant is selected from the group consisting of silica, alumina, carbon black, activated carbon, and antagonistic agents for anti-coagulants.

17. The vascular prosthesis of claim 1, wherein said substance which counteracts the anti-coagulant is present with said elastomer in an amount of about 0.5% to about 10% by weight based on the weight of the elastomer.