Pharmaceuticals having dotted active ingredients and a method and apparatus for the preparation thereof

• US 4,322,449 A
• Filed: 01/03/1980
• Issued: 03/30/1982
• Est. Priority Date: 11/15/1978
• Status: Expired

• Current Assignee: Boehringer Ingelheim GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Gruber, Peter, Voss, Gunther
• Primary Examiner(s): Silverberg, Sam
• Application Number:
  US06/109,420
• Time in Patent Office: 817 Days
• Field of Search: 427/3, 424/16, 424/21, 264/109, 264/128, 264/112, 264/113, 264/134, 222/420-422
• US Class Current: 427/2.14
• CPC Class Codes: A61J 2205/20 Colour codes
• CPC Class Codes: A61J 3/00 Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
• CPC Class Codes: A61K 9/2095 Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: B41J 3/4073 Printing on three-dimensional objects not being in sheet or web form, e.g. spherical or cubic objects B41J3/283, B41J3/286 take precedence; building up a 3D object using individual droplets from jetting heads B29C64/112

Abstract

A method for the preparation of pharmaceuticals which comprises using a piezoelectric dosing system to dot liquid, dissolved or suspended active substance onto a pharmaceutical carrier.

Claims

1. A method for the preparation of solid pharmaceuticals, which comprises dotting liquid, dissolved or suspended active substance in a specific quantity in the form of discrete droplets of specific volume onto a pharmaceutical carrier granulate in a mold before the pharmaceutical carrier granulate is pressed into tablets or cores.

3. The method of claims 1, or 2, wherein the dotting is effected by means of piezoelectric dosing systems.

4. The method of claim 3, wherein a piezoelectric transducer wholly or partly encloses an outlet opening and the dotting is effected in such a way that the release of droplets from a liquid standing under pressure is achieved by the controlled opening of the outlet opening.

5. The method of claims 1, or 2, wherein the liquid, dissolved or suspended active ingredient is broken up under high pressure during passage through a nozzle into discrete droplets of specific volume and the individual droplets are successively charged electrically and intermittently deflected electromagnetically to the desired points of the pharmaceutical carrier.

6. The method of claims 1, or 2, wherein pharmaceutical carriers are dotted in series next to one another with the liquid, dissolved or suspended active substance.

7. The method of claims 1, or 2, wherein the liquid, dissolved or suspended active substance is dotted onto a flat pharmaceutical carrier in desired geometrical distributions.

8. The method of claims 1, or 2, wherein the liquid, dissolved or suspended active substance is dotted onto specific zones of a flat pharmaceutical carrier in doses different from one another.

9. The method of claims 1, wherein the liquid, dissolved or suspended active substance is mixed with a dyestuff and is dotted onto a pharmaceutical carrier to form a coding or letter characters.

2. A method for the preparation of solid pharmaceuticals, which comprises dotting liquid, dissolved or suspended active substance in a specific quantity in the form of discrete droplets of specific volume onto pharmaceutical carrier in the powder bed of an unsealed capsule in a capsule filling machine.