Antithrombogenic articles
First Claim
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1. A medical article of manufacture having a layered nonthrombogenic surface comprising:
- a natural or synthetic polymeric substrate,a chitosan coating bonded to said polymeric substrate, andan antithrombotic agent bonded to said chitosan coating.
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Abstract
A medical article having a layered antithrombogenic surface is useful as a polymeric implant. The article comprises a polymeric substrate coated with chitosan to which is appended an antithrombotic agent. A process for rendering the surface of a polymer antithrombogenic is disclosed.
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Citations
18 Claims
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1. A medical article of manufacture having a layered nonthrombogenic surface comprising:
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a natural or synthetic polymeric substrate, a chitosan coating bonded to said polymeric substrate, and an antithrombotic agent bonded to said chitosan coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A process for rendering the surface of a polymer antithrombogenic comprising the steps:
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(a) priming said polymeric surface so as to render it receptive to the coating of a chitosan salt thereon, (b) coating said chitosan salt from acid solution onto said polymeric surface, (c) reacting the resulting chitosan salt coated polymeric surface with base to convert said chitosan salt to free chitosan, and (d) bonding an antithrombogenic agent to said chitosan coated polymeric article. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. An article of manufacture comprising a self-supporting film of chitosan with an antithrombotic agent bonded thereto.
Specification