Osmotic device with hydrogel driving member
First Claim
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1. An osmotic device for the controlled delivery of a beneficial agent to a fluid environment of use, comprising:
- a. a wall formed of a semipermeable material permeable to the passage of an exterior aqueous fluid present in environment of use and substantially impermeable to the passage of beneficial agent, the semipermeable wall surrounding and forming;
b. a compartment containing a layer of beneficial agent, that is insoluble to very soluble in the aqueous fluid and a layer of an expandable hydrogel; and
,c. a passageway in the semipermeable wall communicating with the layer of beneficial agent in the compartment and with the exterior of the device.
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Abstract
An osmotic device is disclosed comprising a semipermeable wall surrounding a compartment housing an agent that is insoluble to very soluble in aqueous and biological fluids, and a layer of a fluid swellable, hydrogel. A passageway in the wall connects the agent with the exterior of the device.
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Citations
40 Claims
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1. An osmotic device for the controlled delivery of a beneficial agent to a fluid environment of use, comprising:
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a. a wall formed of a semipermeable material permeable to the passage of an exterior aqueous fluid present in environment of use and substantially impermeable to the passage of beneficial agent, the semipermeable wall surrounding and forming; b. a compartment containing a layer of beneficial agent, that is insoluble to very soluble in the aqueous fluid and a layer of an expandable hydrogel; and
,c. a passageway in the semipermeable wall communicating with the layer of beneficial agent in the compartment and with the exterior of the device. - View Dependent Claims (2, 3, 4, 5, 6, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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7. An osmotic device for the controlled delivery of a beneficial drug to a biological environment of use, comprising:
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a. a shaped wall formed of a semipermeable material permeable to the passage of an exterior fluid present in the environment of use, and substanitially impermeable to the passage of drug, the wall surrounding and forming; b. a compartment comprising a drug that is soluble to very soluble in the biological fluid and exhibits an osmotic pressure gradient across the wall against the exterior fluid, and a layer of an expandable hydrogel in contact with the drug formation, which hydrogel can expand from a rested to an expanded state in the presence of exterior fluid imbibed into the compartment; and
,c. a passageway in the wall communicating with the exterior of the device and the drug for delivering the drug formulation from the device at a controlled rate over a prolonged period of time. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26)
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19. An osmotic device for the controlled delivery of a beneficial drug formulation to a biological environment of use, comprising:
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a. a shaped semipermeable wall permeable to the passage of an exterior biological fluid and substantially impermeable to the passage of drug formulation, the wall surrounding and forming; b. a compartment comprising a drug formulation, which formulation comprises a drug that is insoluble to poorly soluble in the biological fluid and an osmotically effective solute that is soluble in the exterior fluid and exhibits an osmotic pressure gradient across the wall against the fluid, and a layer of a hydrogel in contact with the drug formulation, which hydrogel can absorb fluid that enters the compartment and swell; and
,c. a passageway in the semipermeable wall connecting the exterior of the device and drug formulation for delivering the drug formulation from the device to the environment at a controlled rate over a prolonged period of time. - View Dependent Claims (27)
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Specification