Hapten compositions

• US 4,329,281 A
• Filed: 12/21/1979
• Issued: 05/11/1982
• Est. Priority Date: 06/05/1978
• Status: Expired due to Term

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Christenson, James G., Pecherer, Benjamin
• Primary Examiner(s): Fagelson, Anna P.
• Application Number:
  US06/106,347
• Time in Patent Office: 872 Days
• Field of Search: 424/8, 424/12, 424/85, 424/88, 424/177, 260/112 R, 260/112 B, 260/121, 23/230 B
• US Class Current: 530/389.8
• CPC Class Codes: C07D 207/46 with hetero atoms directly attached to the ring nitrogen atom
• CPC Class Codes: G01N 33/946 CNS-stimulants, e.g. cocaine, amphetamines
• CPC Class Codes: Y10S 436/822 Identified hapten
• CPC Class Codes: Y10S 530/806 Antigenic peptides or proteins

Abstract

Novel hapten compositions consisting of 4-[4-[2-(aminopropyl)]phenyl]butanoic acid and its N-methyl derivative are useful in preparing immunogens which can be respectively employed in the elicitation of antibodies selective to amphetamine and methamphetamine. These antibodies can be used as reagents in immunoassays for these two compounds.

Claims

1. An antibody specific to amphetamine prepared by inoculating a host animal with an immunogen of the formula ##STR8## which is covalently bonded through the carboxyl group to an immunogenic carrier material, where R₁ is hydrogen and R₂ is hydrogen, and thereafter collecting serum from said host animal.

3. The antibody of claim 1 or 2 wherein said immunogenic carrier material is bovine serum albumen.

2. An antibody specific to methamphetamine prepared by inoculating a host animal with an immunogen of the formula ##STR9## which is covalently bonded through the carboxyl group to an immunogenic carrier material, where R₁ is methyl and R² is hydrogen and thereafter collecting serum from said host animal.