Amphoteric-nonionic based antimicrobial shampoo

• US 4,329,335 A
• Filed: 11/10/1980
• Issued: 05/11/1982
• Est. Priority Date: 11/10/1980
• Status: Expired due to Term

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Su, Dean T., Schubert, Warren R.
• Primary Examiner(s): Moyer, Donald B.
• Application Number:
  US06/205,536
• Time in Patent Office: 547 Days
• Field of Search: 424/70, 424/71, 424/273 R, 424/DIG. 4, 252/DIG. 13
• US Class Current: 424/70.17
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/442 substituted by amido group(s)
• CPC Class Codes: A61K 8/4946 Imidazoles or their condensed derivatives, e.g. benzimidazoles
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: Y10S 424/04 Dandruff

Abstract

A homogeneous liquid amphoteric-nonionic based antidandruff conditioning shampoo which includes about 0.5 to 2.5% of the antimicrobial agent, 1-imidazolyl-1-(4-chlorophenoxy)-3,3-dimethylbutan-2-one, solubilized in an aqueous solution of critical amounts of a four component mixture of the following specific ingredients:

a. about 6-30% by weight of cocobetaine, cocosulfobetaine, cocoamidobetaine, cocoamidosulfobetaine or combinations thereof,

b. about 1-7.5% by weight of a tertiary amine oxide,

c. about 1-7% by weight of a fatty acid mono- or di-ethanolamide,

d. about 0.1-5.0% by weight of a polyoxyethylene hexitan mono-higher fatty acid ester, and preferably

e. about 0.01-0.1% by weight of a polymerized quaternized ammonium compound. This shampoo is transparent in appearance and should preferably contain 65-80% water.

Claims

1. A homogeneous liquid amphoteric-nonionic based antimicrobial conditioning shampoo containing about 0.5-2.5% of the water insoluble antimicrobial compound, 1-imidazolyl-1-(4-chlorophenoxy)-3,3-dimethylbutan-2-one, solubilized in an aqueous vehicle comprising:

a. about 6-30% by weight of a betaine, sulfobetaine, amidobetaine, amidosulfobetaine or combinations thereof,

b. about 1-7.5% by weight of a dimethyl higher alkyl tertiary amine oxide,

c. about 1-7% by weight of a higher fatty acid mono- or di-ethanolamide,

d. about 0.1-5% by weight of a polyoxyethylene hexitan mono-higher fatty acid ester containing 10-80 moles ethylene oxide per mole, and

e. about 65-80% water.

2. A shampoo in accordance with claim 1, wherein the polyoxyethylene hexitan monoester is polyoxyethylene sorbitan monolaurate containing 20 mol ethylene oxide per mol.

3. A shampoo in accordance with claim 2, wherein the amine oxide is myristyl dimethyl amine oxide.

4. A shampoo in accordance with claim 3, wherein the ethanolamide is lauric myristic diethanolamide.

5. A shampoo in accordance with claim 4, wherein the betaine is cocodimethyl betaine.

6. A shampoo in accordance with claim 1, wherein the aqueous vehicle contains about 0.01-0.1% by weight of a polymerized quaternized ammonium compound having the formula:

##STR6## wherein R is a hydrogen or methyl and n is an integer in the range of 500 to 1,000.

7. A shampoo in accordance with claim 1, wherein the shampoo is a clear liquid.

8. A shampoo in accordance with claim 7, wherein the aqueous vehicle comprises about 7.5-15% by weight of an amphoteric agent selected from the group consisting of betaines, sulfobetaines, amidobetaines, amidosulfobetaines and mixtures thereof;

about 1.0-2.5% by weight of a polyoxyethylene hexitan mono-higher fatty acid ester having 20 moles of ethylene per mol;

about 3-5% by weight of dimethyl higher alkyl tertiary amine oxide and about 1-7% by weight of a higher fatty acid mono- or diethanolamide.

9. A method of simultaneously cleansing, and conditioning the hair in a single operation by shampooing with the liquid composition of claim 1.