Bio-absorbable composite tissue scaffold

• US 4,329,743 A
• Filed: 04/27/1979
• Issued: 05/18/1982
• Est. Priority Date: 04/27/1979
• Status: Expired due to Term

• Current Assignee: University of Medicine and Dentistry of New Jersey (State of New Jersey)
• Original Assignee: College of Medicine and Dentistry of New Jersey
• Inventors: Alexander, Harold, Parsons, John R., Strauchler, Irving D., Weiss, Andrew B.
• Primary Examiner(s): Crowder, Clifford D.
• Application Number:
  US06/033,945
• Time in Patent Office: 1,117 Days
• Field of Search: 3/1, 3/1.9, 128/92 C, 128/334 R, 128/335.5, 128/DIG. 8, 427/2, 428/408, 424/12 S
• US Class Current: 623/13.18
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2/30965 Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/443 with carbon fillers
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10T 428/30 Self-sustaining carbon mass or layer with impregnant or other layer

Abstract

The invention comprises a bio-compatible composition suitable for constructing surgical articles for the repair or replacement of a part of the body of a human or non-human animal, e.g., ligaments, tendons, bones, comprising a composite of a bio-absorbable polymer and at least one substrate of a plurality of carbon fibers.

The invention also includes surgical articles fabricated from the composites for the repair of damaged tissue, e.g., tendons, ligaments and bones.

The invention includes a method for the formation of the aforesaid composite comprising providing a substrate of the carbon fibers and providing the substrate with a continuous coating of a bio-absorbable polymer.

The invention also includes the surgical repair of a damaged body part such as a ligament, tendon or bone comprising surgically affixing to the damaged part the surgical article, the bio-absorbable polymer being absorbed by the body upon formation of the new tissue.

Claims

1. A bio-compatible composition suitable for fabricating a non-migratory surgical article for the repair or replacement of ligament or tendon fibrous tissue of a human or non-human animal comprising a substrate of a plurality of carbon fibers completely enveloped by a bio-absorbable and bio-compatible polylactic acid polymer, wherein the longitudinal axes of said carbon fibers are oriented in substantially the same direction and wherein said fibers provide a scaffold which promotes the growth of new fibrous tissue which is oriented substantially parallel to the longitudinal axes of said carbon fibers.

2. The composition of claim 1, wherein each of said carbon fibers has a diameter in the range of from about 5 to about 15 microns.

3. The composition of claim 1, wherein each of said carbon fibers has a diameter of about 10 microns.

4. The composition of claim 1, wherein the said composite contains from about 30 to about 90%, by weight, of carbon fibers.

5. The composition of claim 1, wherein the said composite contains about 80%, by weight, of carbon fibers.

6. The composition of claim 1, wherein the said composite contains about 50%, by weight, of carbon fibers.

7. The composition of claim 1, wherein said at least one substrate comprises a substantially uniplanar layer of carbon fibers.

8. The composition of claim 7, wherein said composite comprises a plurality of said uniplanar layers in a stacked relationship, each of said layers being separated from the next adjacent layer by a layer of said bio-absorbable polymer.

9. A bio-compatible non-migratory surgical article suitable for incorporation in the body of a human or non-human animal for the repair or replacement of ligament or tendon fibrous tissue thereof, said article constructed of a composite of at least one substrate of a plurality of carbon fibers completely enveloped by a bio-absorbable and bio-compatible polylactic acid polymer, wherein the longitudinal axes of said carbon fibers are oriented in substantially the same direction and wherein said fibers provide a scaffold which promotes the growth of new fibrous tissue which is oriented substantially parallel to the longitudinal axes of said carbon fibers.

10. The article of claim 9, wherein each of said carbon fibers has a diameter in the range of from about 5 to about 15 microns.

11. The article of claim 9, wherein each of said carbon fibers has a diameter of about 10 microns.

12. The article of claim 9, wherein the said composite contains from about 30 to about 90%, by weight, of carbon fibers.

13. The article of claim 9, wherein the said composite contains about 80%, by weight, of carbon fibers.

14. The composition of claim 9, wherein the said composite contains about 50%, by weight, of carbon fibers.

15. The article of claim 9, wherein said at least one substrate comprises a substantially uniplanar layer of carbon fibers.