Treatment of an extracorporeal stream of blood with a dialyzable chemotherapeutic and a fluorescable tracer
First Claim
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1. A method for treating whole blood with a dialyzable chemotherapeutic agent in an extracorporeal stream of said blood which comprises:
- removing whole blood from a patient and forming the whole blood into an extracorporeal stream;
introducing into the extracorporeal stream said chemotherapeutic agent together with a fluorescable tracer means that is dialyzable therefrom at a rate that is a function of the dialysis rate for the chemotherapeutic agent, said fluorescable tracer means being a member of the group consisting of an N-substituted benzamide represented by the formula ##STR2## wherein R is a member of the group consisting of hydrogen and methyl, X is a member of the group consisting of halogen and alkoxy having no more than two carbon atoms, and n is an integer having a value of 0 or 1, and physiologically tolerable alkali metal salts thereof;
dialyzing the extracorporeal stream so as to remove therefrom in a dialysate the chemotherapeutic agent and the tracer means at respective rates that are a function of one another;
irradiating a portion of the obtained dialyzate with fluorescence-exciting electromagnetic radiation;
passing the irradiated portion over a detector means responsive to fluorescence emitted by the tracer means present in said portion and generating an electrical signal having a magnitude indicative of the intensity of emitted fluorescence;
energizing an indicator means with the generated signal;
and returning the blood to the patient.
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Abstract
A therapeutic composition suitable for extracorporeal treatment of whole blood comprises a dialyzable chemotherapeutic agent and a dialyzable fluorescable tracer means. The removal rate of the fluorescable tracer compound from treated blood during hemodialysis is a function of the removal rate of unreacted chemotherapeutic agent present. The residual chemotherapeutic agent concentration after hemodialysis is ascertained by measuring the concentration of the fluorescable tracer compound in a dialysate using fluorometric techniques.
32 Citations
13 Claims
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1. A method for treating whole blood with a dialyzable chemotherapeutic agent in an extracorporeal stream of said blood which comprises:
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removing whole blood from a patient and forming the whole blood into an extracorporeal stream; introducing into the extracorporeal stream said chemotherapeutic agent together with a fluorescable tracer means that is dialyzable therefrom at a rate that is a function of the dialysis rate for the chemotherapeutic agent, said fluorescable tracer means being a member of the group consisting of an N-substituted benzamide represented by the formula ##STR2## wherein R is a member of the group consisting of hydrogen and methyl, X is a member of the group consisting of halogen and alkoxy having no more than two carbon atoms, and n is an integer having a value of 0 or 1, and physiologically tolerable alkali metal salts thereof; dialyzing the extracorporeal stream so as to remove therefrom in a dialysate the chemotherapeutic agent and the tracer means at respective rates that are a function of one another; irradiating a portion of the obtained dialyzate with fluorescence-exciting electromagnetic radiation; passing the irradiated portion over a detector means responsive to fluorescence emitted by the tracer means present in said portion and generating an electrical signal having a magnitude indicative of the intensity of emitted fluorescence; energizing an indicator means with the generated signal; and returning the blood to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for treating whole blood with a dialyzable chemotherapeutic agent in an extracorporeal stream of said blood which comprises:
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removing whole blood from a patient and forming the whole blood into an extracorporeal stream; introducing into the extracorporeal stream said chemotherapeutic agent together with a fluorescable tracer means that is dialyzable therefrom at a rate that is a function of the dialysis rate for the chemotherapeutic agent, said fluorescable tracer means being a member of the group consisting of an N-substituted benzamide represented by the formula ##STR3## wherein R is a member of the group consisting of hydrogen and methyl, X is a member of the group consisting of halogen and alkoxy having no more than two carbon atoms, and n is an integer having a value of 0 or 1, and physiologically tolerable alkali metal salts thereof; dialyzing the extracorporeal stream so as to remove therefrom the chemotherapeutic agent and the tracer means at respective rates that are a function of one another; contacting for a predetermined time period at least a portion of the dialyzed extracorporeal stream across a dialysis membrane with an aqueous secondary dialysis solution devoid of said tracer means; thereafter recovering said aqueous secondary dialysis solution; irradiating an aliquot of the recovered aqueous secondary dialysis solution with fluorescence exciting electromagnetic radiation; passing the irradiated aliquot over a detector means responsive to fluorescence emitted by the tracer means present in said aliquot and generating an electrical signal having a magnitude indicative of the intensity of emitted fluorescence; energizing an indicator means with the generated signal; and returning the blood to the patient. - View Dependent Claims (9, 10, 11, 12, 13)
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Specification