Laminate made of a cellulose acetate layer and an elastomeric material layer

• US 4,331,728 A
• Filed: 12/10/1979
• Issued: 05/25/1982
• Est. Priority Date: 10/11/1978
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Theeuwes, Felix
• Primary Examiner(s): CANNON, JAMES
• Application Number:
  US06/101,870
• Time in Patent Office: 897 Days
• Field of Search: 428/496, 428/508, 428/509, 428/510, 428/215, 428/216, 210/500 M
• US Class Current: 428/215
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: B32B 23/08 of synthetic resin
• CPC Class Codes: B32B 2439/00 Containers; Receptacles closures therefor B32B2435/00
• CPC Class Codes: Y10T 428/24967 Absolute thicknesses specified
• CPC Class Codes: Y10T 428/24975 No layer or component greater than 5 mils thick
• CPC Class Codes: Y10T 428/31841 Next to cellulosic
• CPC Class Codes: Y10T 428/31884 Regenerated or modified cellulose
• CPC Class Codes: Y10T 428/31888 Addition polymer of hydrocarbon[s] only
• CPC Class Codes: Y10T 428/31891 Where addition polymer is an ester or halide

Abstract

An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway through the wall for delivering agent from the compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent. The compartment contains (1) an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or (2) the compartment contains an agent having limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against the fluid. The compartment also contains along with (1) or (2) a volume amplifier for increasing the amount of agent delivered from the system. The amplifier comprises a membrane surrounding a gas generating couple with the membrane formed of an expandable material permeable to fluid and impermeable to the couple. In operation, agent is delivered from the system through the passageway at a controlled rate by fluid being imbibed through the wall into the compartment to produce a solution of (1), or a suspension of (2), and for imbibition by the amplifier causing the couple to generate gas and continuously fill the amplifier thereby urging it to increase in volume and fill the compartment whereby agent (1) or (2) is released at a rate controlled by the permeability of the wall, the osmotic pressure gradient across the wall, and the rate of imbibition and increase in volume of the amplifier over a prolonged period of time.

Claims

1. A laminate useful for manufacturing a dispensing device, said laminate consisting of a lamina formed of an elastomeric member selected from the group of polymers consisting of rubber, polyisoprene, polyisobutylene, polybutadiene, ethylene-propylene copolymer, and butylene-vinyl acetate copolymer, laminated to a lamina formed of a cellulose polymeric member selected from the group consisting of cellulose acetate, cellulose diacetate and cellulose triacetate, which cellulosic polymer contains from 0.01% to 40% of a member selected from the group consisting of a polyhydric alcohol, a polyalkylene glycol, a poly(α

-W-alkylenediol) and a polyester of an alkylene glycol.

2. The laminate useful for manufacturing the dispensing device according to claim 1 wherein the lamina comprising the elastomeric member is from 1 to 10 mils thick, and the lamina comprising the cellulose member is from 1 to 10 mils thick.