9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
First Claim
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1. A compound of the formula ##STR8## wherein:
- R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and
R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms; and
the pharmaceutically acceptable acid addition salts thereof.
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Abstract
Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula ##STR1## wherein: R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and
R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms; and
the pharmaceutically acceptable acid addition salts thereof.
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Citations
20 Claims
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1. A compound of the formula ##STR8## wherein:
- R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and
R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms; and
the pharmaceutically acceptable acid addition salts thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and
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18. A pharmaceutically composition comprising 5 to 95% by weight of a compound of the formula ##STR9## or a pharmaceutically acceptable acid addition salt thereof, wherein:
- R, R1, R2, R3, and R4 are independently hydrogen, or lower alkyl of one to four carbon atoms;
R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms;
in admixture with 90 to 10% of a pharmaceutically acceptable, non-toxic carrier.
- R, R1, R2, R3, and R4 are independently hydrogen, or lower alkyl of one to four carbon atoms;
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19. A method for treating and/or preventing hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders and asthma in a mammalian subject comprising administering to said subject a therapeutically effective amount of a compound of the formula ##STR10## or a pharmaceutically acceptable acid addition salt thereof, wherein:
- R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and
R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms or a pharmaceutical composition containing such compound as an active ingredient. - View Dependent Claims (20)
- R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and
Specification
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Current AssigneeDonald Kaplan
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Original AssigneeSyntec Incorporated (Atos SE)
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InventorsClark, Robin D.
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Primary Examiner(s)Love, Ethel G.
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Application NumberUS06/246,459Time in Patent Office435 DaysField of Search544/71, 424/248.57US Class Current514/230.8CPC Class CodesA61P 11/00 Drugs for disorders of the ...A61P 43/00 Drugs for specific purposes...A61P 9/04 Inotropic agents, i.e. stim...A61P 9/06 AntiarrhythmicsA61P 9/08 Vasodilators for multiple i...A61P 9/12 AntihypertensivesC07D 211/48 having an acyclic carbon at...
