Hypoglycemic 5-substituted oxazolidine-2,4-diones
First Claim
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1. A compound of the formula ##STR12## wherein R is hydrogen, (C1 -C4)-alkanoyl, benzoyl, (C2 -C4)-carbalkoxy, (C1 -C3)-alkylcarbamoyl or di(C1 -C3)-alkylcarbamoyl;
- Y is sulfur or oxygen;
X is hydrogen, fluoro, chloro, bromo, iodo, methyl, phenyl, benzoyl, or (C1 -C3)-alkoxy;
X1 is hydrogen or methyl; and
X2 is hydrogen, fluoro, bromo, chloro or iodo;
or a pharmaceutically acceptable cationic salt thereof when R is hydrogen.
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Abstract
Hypoglycemic 5-furyl and 5-thienyl derivatives of oxazolidine-2,4-dione and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; and intermediates useful in the preparation of said compounds.
29 Citations
23 Claims
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1. A compound of the formula ##STR12## wherein R is hydrogen, (C1 -C4)-alkanoyl, benzoyl, (C2 -C4)-carbalkoxy, (C1 -C3)-alkylcarbamoyl or di(C1 -C3)-alkylcarbamoyl;
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Y is sulfur or oxygen; X is hydrogen, fluoro, chloro, bromo, iodo, methyl, phenyl, benzoyl, or (C1 -C3)-alkoxy; X1 is hydrogen or methyl; and X2 is hydrogen, fluoro, bromo, chloro or iodo;
or a pharmaceutically acceptable cationic salt thereof when R is hydrogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification
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Current AssigneePfizer Inc.
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Original AssigneePfizer Inc.
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InventorsSchnur, Rodney C.
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Primary Examiner(s)Sutto, Anton H.
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Assistant Examiner(s)Gibson, Sharon A.
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Application NumberUS06/252,961Time in Patent Office404 DaysField of Search548/226US Class Current548/226CPC Class CodesA61P 3/10 for hyperglycaemia, e.g. an...C07C 45/513 the singly bound functional...C07D 405/04 directly linked by a ring-m...C07D 409/04 directly linked by a ring-m...
