Control of dialysis and ultrafiltration

• US 4,334,988 A
• Filed: 08/04/1980
• Issued: 06/15/1982
• Est. Priority Date: 12/30/1975
• Status: Expired due to Term

• Current Assignee: Hospal Medical Corporation
• Original Assignee: Hospal Medical Corporation
• Inventors: Milligan, Lee J.
• Primary Examiner(s): Spear, Jr., Frank A.
• Application Number:
  US06/174,856
• Time in Patent Office: 680 Days
• Field of Search: 210/637, 210/89, 210/646, 210/321.3, 210/647, 210/416.1, 210/744, 210/746
• US Class Current: 210/87
• CPC Class Codes: A61M 1/1694 with recirculating dialysing liquid
• CPC Class Codes: B01D 61/22 Controlling or regulating
• CPC Class Codes: B01D 61/32 Controlling or regulating
• CPC Class Codes: Y10S 210/929 Hemoultrafiltrate volume measurement or control processes

Abstract

Method and apparatus are disclosed for controlling dialysis and ultrafiltration. Precision control over the operation of an artificial kidney (dialyzer), particularly the removal of waste water by ultrafiltration, is achieved by the use of two pumps in the respective paths to and from the artificial kidney. One of the pumps may be operated at constant speed and the other at a variable speed under control from a level sensor at the storage tank, whereby a prescribed rate of ultrafiltration is maintained by a third pump. If desired, the pumps may be operated at complementary speeds so that as the speed of one is increased, the speed of the other is decreased, maintaining a prescribed rate of ultrafiltration by a third pump, under the control of the level sensors at the tank. A further feature provides automatic switching back and forth between two storage tanks of blood cleansing fluid (dialysate) in conjunction with the two pumps in the respective paths to and from the artificial kidney.

The fluid systems are open to the atmosphere rather than being physically enclosed. The maintenance of an essentially constant volume of blood cleansing fluid (dialysate) within the apparatus is dependent upon the use of feedback control of the relative pump speeds derived from a fluid level sensor within the open dialysis liquid tank.

Claims

1. A dialysis and ultrafiltration control system for controlling ultrafiltration taking place across a semipermeable membrane device, which comprises a dialysis liquid tank for containing dialysis liquid and which is open to the atmosphere, a level sensor for detecting the level of dialysis liquid contained in the open dialysis liquid tank, dialysis liquid withdrawal means in communication with the open dialysis liquid tank for withdrawing determined volumes of dialysis liquid, means for effecting the circulation of the stream of dialysis liquid which means includes two positive-flow pumps, one disposed upstream and the other downstream of the dialyzer so that the ultrafiltration of liquid being treated is adjusted, and feedback means leading from said level sensor to said positive-flow pumps, wherein the means for controlling ultrafiltration constitutes controlling the operation of the two pumps in relation to each other in response to the level of dialysis liquid sensed in the tank in such manner as to maintain a substantially constant level of dialysis liquid in said tank at a determined rate of withdrawal of dialysis liquid.

2. A dialysis and ultrafiltration control system as defined in claim 1, wherein one of the two positive-flow pumps is driven by a constant speed motor and the other is driven by a variable speed motor.

3. A dialysis and ultrafiltration control system as defined in claim 2, where the pump driven by the constant speed motor is disposed upstream of the dialyzer and the other pump is disposed downstream of the dialyzer, and means for increasing the speed of the variable speed motor when the level of dialysis liquid in the tank decreases and vice versa.

4. A dialysis and ultrafiltration control system as defined in claim 2, where the pump driven by the constant speed motor is disposed downstream of the dialyzer and the other pump is disposed upstream of the dialyzer, and means for decreasing the speed of the variable speed motor when the level of dialysis liquid in the tank increases and vice versa.

5. A dialysis and ultrafiltration control system as defined in claim 1, wherein each of the two pumps is driven by a variable speed motor.

6. A dialysis and ultrafiltration control system as defined in claim 5, including means for increasing the speed of the variable speed motor driving the downstream pump when the level of dialysis liquid in the tank decreases and vice versa.

7. A dialysis and ultrafiltration control system as defined in claim 5, including means for decreasing the speed of the variable speed motor driving the upstream pump when the level of dialysis liquid in the tank increases and vice versa.

8. A dialysis and ultrafiltration control system as defined in claim 1, including means for monitoring a substantially constant rate of flow of dialysis liquid in the dialyzer.