Method of avoiding and removing adhesions

• US 4,337,251 A
• Filed: 05/06/1980
• Issued: 06/29/1982
• Est. Priority Date: 05/09/1979
• Status: Expired due to Term

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Pfirrmann, Rolf W.
• Primary Examiner(s): Cacciapaglia, Jr., Frank
• Application Number:
  US06/147,231
• Time in Patent Office: 784 Days
• Field of Search: 424/246
• US Class Current: 514/222.5
• CPC Class Codes: A61K 31/54 having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention provides a method of treatment of the human or animal body comprising the application of an aqueous solution containing a compound of formula I ##STR1## [wherein R¹ represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R² represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula II ##STR2## in which R¹ is as defined above] to human or animal tissue subjected to surgical treatment whereby the incidence of adhesion formation is eliminated or substantially reduced or whereby existing adhesions are at least substantially detached or unblocked. There is also provided a solution for use in the above method.

Claims

1. A method of treatment of a human or animal in need of said treatment comprising the application of an aqueous solution containing a compound of formula I ##STR5## wherein R¹ represents a hydrogen atom and R² represents a hydrogen atom or a group of formula II ##STR6## in which R¹ is as defined above to human or animal tissue subjected to surgical treatment where no bacterial infection is present whereby the incidence of adhesion formation is eliminated or substantially reduced or whereby existing adhesions are at least substantially detached or unblocked.

2. A method as claimed in claim 1 wherein the said application is effected for at least part of the time from shortly before to shortly after the said surgical treatment.

3. A method as claimed in claim 1 wherein the concentration of the said compound of formula I in the said aqueous solution is from 0.5 to 5% by weight.

4. A method as claimed in any one of claims 1 to 3 wherein the said compound of formula I is bis-(1,1-dioxo-perhydro-1,2,4-thiadiazin-4-yl)-methane.

5. A method as claimed in claim 4 wherein the dosage of bis-(1,1-dioxo-perhydro-1,2,4-thiadiazin-4-yl)-methane is from 2 to 20 g per day for an adult human.

6. A method as claimed in claim 1 wherein the said aqueous solution further contains polyvinylpyrrolidone.

7. A method as claimed in claim 6 wherein the molecular weight of the polyvinylpyrrolidone is less than 30,000.

8. A method as claimed in claim 6 wherein the molecular weight of the polyvinylpyrrolidone is less than 10,000.

9. A method as claimed in claim 6 wherein the molecular weight of the polyvinylpyrrolidone is from 2,000 to 3,500.

10. A method as claimed in claim 1 wherein the said solution is applied by instillation or by infusion.

11. A method as claimed in claim 1 wherein the said surgical treatment involves surgery of the peritoneum, the heart or the fallopian tube.

12. A method of treatment of a human or animal in need of said treatment comprising the application of an aqueous solution containing a compound of formula I ##STR7## wherein R¹ represents a hydrogen atom and R² represents a hydrogen atom or a group of formula II ##STR8## in which R¹ is as defined above to human or animal tissue subjected to surgical treatment whereby existing adhesions are at least substantially detached or unblocked.

13. A method as claimed in claim 12 wherein the said application is effected for at least part of the time from shortly before to shortly after the said surgical treatment.

14. A method as claimed in claim 12 wherein the concentration of the said compound of formula I in the said aqueous solution is from 0.5 to 5% by weight.

15. A method as claimed in any one of claims 12 to 14 wherein the said compound of formula I is bis-(1,1-dioxo-perhydro-1,2,4-thiadiazin-4-yl)-methane.

16. A method as claimed in claim 12 wherein the said solution is applied by instillation or by infusion.

17. A method as claimed in claim 12 wherein the said surgical treatment involves surgery of the peritoneum, the heart or the fallopian tubes.

18. A method as claimed in claim 12 wherein the said aqueous solution further contains polyvinylpyrrolidone.

19. A method as claimed in claim 18 wherein the molecular weight of the polyvinylpyrrolidone is less than 30,000.