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1-Hydroxylation process

  • US 4,338,250 A
  • Filed: 04/27/1981
  • Issued: 07/06/1982
  • Est. Priority Date: 04/27/1981
  • Status: Expired due to Term
First Claim
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1. A process for preparing 1α

  • -hydroxy-5,6-trans-vitamin D compounds which comprises, treating a 5,6-cis-vitamin D compound having the formula ##STR3## wherein X is selected from the group consisting of hydrogen, hydroxy and protected-hydroxy, and R is any sidechain substituent desired in the 1α

    -hydroxy-5,6-trans-vitamin D product,with iodine and a mixture of SeO2 and a hydroperoxide in the presence of organic nitrogenous base, and recovering the desired 1α

    -hydroxy-5,6-trans-vitamin D product.

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