Method of increasing the incidence of female offspring

• US 4,339,434 A
• Filed: 08/17/1981
• Issued: 07/13/1982
• Est. Priority Date: 08/17/1981
• Status: Expired due to Term

• Current Assignee: Gametrics Limited
• Original Assignee: Gametrics Limited
• Inventors: Ericsson, Ronald J.
• Primary Examiner(s): Rosen, Sam
• Application Number:
  US06/293,079
• Time in Patent Office: 330 Days
• Field of Search: 424/105, 128/1 R
• US Class Current: 424/561
• CPC Class Codes: A61K 35/52 Sperm; Prostate; Seminal fluid; Leydig cells of testes

Abstract

The likelihood of conceiving a female fetus is substantially enhanced by promoting ovulation in a fertile female mammal with an ovulation-inducing agent and artificially inseminating the female mammal during the period of expected ovulation with a sperm fraction of enhanced sperm motility from which immotile sperm and non-sperm seminal components have been separated and which is suspended in serum albumin or like physiologically acceptable vehicle.

Claims

1. A method for promoting the conception of a female fetus in a fertile female mammal for whom a female offspring is desired, which comprises the steps of inducing ovulation in the female mammal with an ovulation inducing agent and thereafter artificially inseminating the female mammal proximate the time of ovulation with a motile sperm enriched fraction of sperm of that mammal from which immotile sperm and non-sperm components of the semen have been separated and which is suspended in a liquid vehicle which is physiologically acceptable to the sperm.

2. A method according to claim 1 wherein the mammal is a human being.

3. A method according to claim 2 wherein the human being is inseminated cervically.

4. A method according to claim 1 wherein the ovulation inducing agent is clomiphene.

5. A method according to claim 1 wherein the ovulation inducing agent is gonadotrophin.

6. A method according to claim 1 wherein the suspending liquid vehicle is an aqueous solution of human serum albumin.

7. A method according to claim 1 wherein the sperm is enriched in Y-sperm.

8. A method according to claim 1 wherein the mammal is a human being and is cervically inseminated with sperm which is enriched in Y-sperm.

9. A method according to claim 8 wherein the ovulation inducing agent is clomiphene.

10. A method according to claim 1 wherein the liquid vehicle is an aqueous solution of human serum albumin.

11. A method according to claim 1 wherein the mammal is a bovine.