Self-driven hypodermic injector

• US 4,340,048 A
• Filed: 03/28/1981
• Issued: 07/20/1982
• Est. Priority Date: 03/28/1981
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US06/246,595
• Time in Patent Office: 479 Days
• Field of Search: 128/260, 128/213 R, 128/214 F, 128/268, 128/215, 128/216, 128/230, 128/232, 128/218 R, 128/218 N
• US Class Current: 604/890.1
• CPC Class Codes: A61J 1/06 Ampoules or carpules syringe ampoules or carpules A61M5/28
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons

Abstract

A self-driven hypodermic injector that injects an injectable pharmaceutical composition at a constant baseline rate and may be manipulated to supplement the baseline rate with one or more pulses of the composition. The injector consists of a tubular housing with one fixed basal end wall that carries a hollow small gauge needle and one axially moveable end wall; an axially slideable water imbibing assembly mounted transversely in the housing lumen that divides the lumen into a pharmaceutical composition-containing compartment contiguous to the basal end wall and a water-containing compartment. In operation the subassembly imbibes water from the water-containing compartment and expands into the pharmaceutical-containing compartment to displace the pharmaceutical therefrom at the baseline rate. Pulses are effected by depressing the axially moveable end wall which in turn slides the subassembly toward the fixed end wall thereby exerting pressure on the pharmaceutical composition and increasing the injection rate.

Claims

1. A self-driven hypodermic injector for injecting an injectable pharmaceutical preparation into a patient according to a controlled dosage regimen comprising

(a) a hollow closed rigid body;

(b) a water imbibing member mounted within the body that divides the lumen of the body into a first compartment adapted to hold the pharmaceutical preparation and a second compartment adapted to hold an aqueous liquid, the member comprising;

(i) a rigid semipermeable wall that faces the second compartment;

(ii) an expandable impermeable wall that faces the first compartment; and

(iii) a water imbibing composition contained between the rigid semipermeable wall and the expandable impermeable wall; and

(c) a conduit that extends through the wall of the body, one end of which opens into the first compartment and the other end of which is adapted to pierce the skin of the patient.

2. The injector of claim 1 wherein the water imbibing member is mounted within the body such that the member is not capable of movement other than the expansion of said expandable impermeable wall.

3. The injector of claim 1 wherein the water imbibing member is able to slide toward the first compartment and the injector includes:

(d) manually operable means for exerting a force on the member to cause it to slide within the body toward the first compartment.

15. The injector of claim 1 including (d) manually operable means for exerting pressure on the pharmaceutical composition.

16. The injector of claim 15 wherein the means is an opening through the wall of the body to the first compartment and a piston that fits into the opening.

4. A self-driven hypodermic injector for injecting an injectable pharmaceutical preparation into a patient according to a controlled dosage regimen comprising:

(a) a rigid tubular housing have a pair of end walls that close the ends of the housing, one of the end walls providing a basal surface that is adapted to be placed against the skin of the patient;

(b) a water imbibing member mounted transversely within the housing that divides the lumen of the housing into a first compartment that contains the pharmaceutical preparation and is contiguous to the housing end wall that provides said basal surface and a second compartment that contains water, the water imbibing member comprising

(i) a rigid semipermeable wall that faces the second compartment;

(ii) an expandable impermeable wall that faces the first compartment; and

(iii) a water imbibing composition contained between the semipermeable wall and the impermeable wall; and

(c) a hollow needle that extends from the first compartment through the housing end wall that provides the basal surface, one end of the needle opening into the first compartment and the other end of the needle being adapted to pierce the skin of the patient when the basal surface is placed against the skin of the patient.

5. The injector of claim 4 wherein the water imbibing member is mounted within the housing such that the member is not capable of movement other than the expansion of the expandable impermeable wall.

6. The injector of claim 4 wherein the water imbibing member is slideably mounted in the housing such that the member is able to slide toward the end wall that provides the basal surface and the injector includes

(d) manually operable means for exerting a force on the water imbibing member to cause it to slide within the housing toward the end wall that provides the basal surface.

7. The hypodermic injector of claim 4 wherein the water imbibing member includes an axially slideable ring on which the semipermeable wall, expandable impermeable wall, and water imbibing composition are mounted and the other end wall is capable of being depressed axially to bear against the axially slideable ring and drive the water imbibing member toward said one end wall.

8. The hypodermic injector of claim 7 wherein the interior surface of the side of the housing distal from the basal surface is threaded and the other end wall has threads and screws into the housing to effect said axial depression.

9. The hypodermic injector of claim 7 including sealing means between the interior of the housing and the exterior of the axially slideable ring.

10. The hypodermic injector of claim 4 wherein the water-imbibing member includes an axially slideable ring on which the semipermeable wall, expandable impermeable wall and water imbibing composition are mounted, said ring being connected to the other end wall and the other end wall is capable of being depressed axially thereby causing the water imbibing member to slide toward said one end wall.

11. The hypodermic injector of claim 10 including sealing means between the interior of the housing and the exterior of the axially slideable ring.

12. The hypodermic injector of claim 5 wherein the water imbibing composition is a liquid and the injector includes means for manually exerting pressure on the liquid water imbibing composition thereby causing the expandable impermeable wall to expand.

13. The hypodermic injector of claim 12 wherein the water imbibing member includes a support member positioned between the water imbibing composition and the semipermeable wall, the support member having a plurality of axial holes opening to the semipermeable wall and the water imbibing composition and an axial opening defined by a cylindrical axially elongated collar that extends through the semipermeable wall into the second compartment and the other end wall is capable of being depressed axially and carries a piston member that is received in the collar, whereby when the other end wall is depressed pressure is exerted on the water imbibing composition.

14. The hypodermic injector of claim 13 wherein the exterior surface of the side of the housing distal from the basal surface is threaded and the other end wall has interior threads and screws onto the housing to effect said axial depression.