Anti-tumor quinazoline compounds
First Claim
Patent Images
1. A compound having Formula I ##STR14## wherein one of R6 and R7 is oxiranylmethyl, and the other is methyl or oxiranylmethyl, and R2 and R4 are independently selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents, wherein said substituted phenyl and substituted phenylalkyl have one or two ring attached groups independently selected from halogen, methyl, or methoxy groups.
1 Assignment
0 Petitions
Accused Products
Abstract
4-Ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline and its isomer 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline have potent anti-tumor activity in animals.
122 Citations
3 Claims
- 1. A compound having Formula I ##STR14## wherein one of R6 and R7 is oxiranylmethyl, and the other is methyl or oxiranylmethyl, and R2 and R4 are independently selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents, wherein said substituted phenyl and substituted phenylalkyl have one or two ring attached groups independently selected from halogen, methyl, or methoxy groups.
Specification