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Method of delivering drug with aid of effervescent activity generated in environment of use

  • US 4,344,929 A
  • Filed: 01/26/1981
  • Issued: 08/17/1982
  • Est. Priority Date: 04/25/1980
  • Status: Expired due to Term
First Claim
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1. A method for delivering from an osmotic device a drug that is difficult to deliver to an environment of use having a pH of less tha seven, wherein the method comprises:

  • (1) admitting into the environment an osmotic drug delivery device, which device comprises;

    (a) a shaped wall formed of a semipermeable material that is permeable to the passage of fluid present in the environment, and substantially impermeable to the passage of drugs and compounds, which wall surrounds and forms;

    (b) a compartment housing a drug that is difficult to deliver to the environment, and a basic compound having a gas generating moiety, which compound is soluble in fluid that enters the compartment;

    (c) a passageway in the wall connecting the compartment and the exterior of the device for dispensing drug from the device; and

    ,(2) imbibing fluid through the wall into the compartment in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall;

    thereby(3) forming a solution of the basic compound containing drug, which solution is dispensed from the compartment through the passageway into the environment with the compound reactively;

    (4) generating a gas on its contact with the fluid of the environment producing an effervescent suspension that delivers the drug in a finely dispersed form to the environment over a prolonged period of time.

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