Apparatus for preventing the entry of air into an artificial organ

• US 4,345,999 A
• Filed: 09/29/1980
• Issued: 08/24/1982
• Est. Priority Date: 04/27/1978
• Status: Expired due to Term

• Current Assignee: Edward Fresenius Chemisch-Pharmazeutische Industrie KG
• Original Assignee: Dr Eduard Fresenius Chemisch-Pharmazeutische Industrie KG Apparatebau KG
• Inventors: Krick, Gerd, Sigdell, Jan-Erik
• Primary Examiner(s): Spitzer, Robert H.
• Application Number:
  US06/191,378
• Time in Patent Office: 694 Days
• Field of Search: 55/52, 55/159, 55/185, 55/186, 55/190, 55/199, 55/201, 55/36, 55/158, 210/120, 210/180, 210/188, 210/321.2, 210/323.2, 210/428, 210/433.2, 210/434, 210/436, 210/472, 210/539, 422/45, 422/48
• US Class Current: 96/6
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: B01D 2313/10 Specific supply elements
• CPC Class Codes: B01D 61/20 Accessories; Auxiliary operations
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation
• CPC Class Codes: B01D 63/02 Hollow fibre modules
• CPC Class Codes: B01D 63/033 Specific distribution of fibres within one potting or tube-sheet
• CPC Class Codes: B01D 65/00 Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes

Abstract

Air or gas is prevented from entering into the exchange zone of an artificial organ such as an artificial kidney, dialyzer, or hemofilter. For this purpose a separating path is arranged in parallel with the artificial organ or with the exchange zone or other operative portion of the artificial organ between the liquid inflow and outflow conduits. This parallel path is provided with a high flow resistance for the liquid and with a low flow resistance for the air. Such differential flow resistance may, for example, be accomplished by apertures, gas permeable materials, and eddy chambers. The gas separating path is incorporated as an integral part of the artificial organ or as an integral part of the liquid inflow and outflow conduits. According to several embodiments, an enlargement is provided in the separating path or conduit in which the liquid may "rise and dwell" to enhance air separation before the liquid flows into the operative portion of the artificial organ.

Claims

1. A separator for removing gas from a liquid flow before the liquid flow passes into and through an artificial organ and for returning removed gas back into the liquid flow after the liquid flow has passed from an inlet to an outlet of the artificial organ, comprising inflow channel means (20) for coupling to an inlet of the artificial organ;

outflow channel means (27) for coupling to an outlet of the artificial organ, said outflow channel means (27) being positioned over and adjacent to the inflow channel means (20) in its operative position;

common wall means (30) joining the inflow channel means (20) and the outflow channel means (27), said common wall means comprising flow resistance means (25) having a low flow impedance for gases and high flow impedance for liquids, said flow resistance means (25) being connectable in parallel to the artificial organ, whereby gases may pass directly from inflowing liquid back into liquid flowing out of the aritificial organ, thereby passing the artificial organ, said inflow channel means (20) being connectable in series with each other through the artificial organ for generating a pressure drop in said outflow channel means (27) relative to said inflow channel means (20) by liquid flowing out of the artificial organ and through the outflow channel means (27), said pressure drop supporting the withdrawal of gas through said flow resistance means (25) to prevent the entry of gas into an artificial organ.

2. The separator of claim 1, wherein said inflow channel means is formed to comprise a bend having a domed upward configuration in its operative position, said common wall joining the inflow and outflow channel means along the portion of said domed upward configuration.

3. The separator of claim 2, wherein said inflow channel means is enlarged in the region of said domed upward configuration to form an eddy space and gas trap which provides a dwell time for liquid in the inflow channel, and wherein gas rises to the top of said domed upward configuration for passage through the flow resistance means of the common wall means into the outflow channel means, whereby gases in the inflowing liquid substantially bypass the artificial organ or other device and pass directly to the liquid flowing out of the device.

4. The separator of claim 1, wherein said inflow channel means is shaped to form a gas trap, said common wall means being located to form part of said gas trap, and wherein said flow resistance means is located to communicate between said gas trap and the outflow channel means.

5. The separator of claim 1, wherein said flow resistance means include a selectively gas permeable material operating as hydrophobic filter means.

6. The separator of claim 1, wherein said inflow channel means is formed with a convex upward bend and said flow resistance means comprises at least a portion of the upper wall (30) of the channel means at said bend.

7. The separator of claim 6, wherein said inflow channel means is enlarged in the region of the convex upward bend (FIG. 3, 3a) for providing a dwell time volume.

8. The separator of claim 1, further comprising an artificial organ comprising elongated housing means including outer jacket means, hollow core means (2) coaxially within the outer jacket means, said outer jacket means and said core means defining therebetween an annular space, first and second end cover means engaging the outer jacket and core at each end of the housing, follow filament means substantially occupying said annular space, said hollow filament means being bonded together at the ends and having open ends facing the respective end cover means at both ends of said housing means, said end cover means defining at each end of the housing means a ring cavity above the open ends of the hollow filament means, liquid inlet means forming said inflow channel means (11, 12) operatively connected to a lower end of said hollow core means (2) and liquid outlet means (16, 17) forming said outflow channel means operatively connected to said housing means, said artificial organ having said inlet (14) in said lower end of said core (2) substantially adjacent to said inflow channel means (11, 12), flow resistance means (18) in an upper end of said hollow core, said artificial organ having said outlet (15) located substantially adjacent to said outflow channel means at the upper end of said hollow core means, said flow resistance means (18) having a low flow impedance for gases and a high flow impedance for liquid, said pressure drop supporting the withdrawal of gas through said hollow core and returning the withdrawn gas into outflowing liquid.

9. The separator of claim 8, wherein said inflow channel means at the lower end of said hollow core means are oriented for delivering liquid generally upward into the hollow core means, said inlet (14) at the lower end being arranged for delivering said liquid generally downwardly from the hollow core means into said artificial organ, whereby gases entrained in said liquid rise upwardly through the hollow core means and substantially bypass said artificial organ.

10. The separator of claim 9, wherein said inflow chanel means is located centrally in the end of the hollow core means forming auxiliary flow path means while said inlet comprises openings (14) distributed around and radially outwardly from said inflow channel means.

11. The separator of claim 1 or 8, wherein said flow resistance means (25, 18) comprise aperture means small enough to provide a high flow resistance to liquid and a low flow resistance to gas.