Nonthrombogenic articles and method of preparation
First Claim
1. In a method for reducing the thrombogenicity of a solid polymeric resin, which comprises absorbing a quaternary ammonium salt on the surface of the resin and then contacting the surface with the absorbed salt, with a solution of heparin, the improvement which comprises;
- employing as said solution one containing a concentration of heparin within the range of from about 5 percent by weight to saturation.
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Accused Products
Abstract
The disclosure is of articles having reduced thrombogenicity and which are useful for purposes requiring their contact with whole blood. The articles comprise solid, polymeric resin substrates to which there is fixed a compound of the formula: ##STR1## wherein R1 is alkyl of 12 to 18 carbon atoms, inclusive; R2, R3 and R4 are each independently selected from the group consisting of hydrogen and lower alkyl; X represents a negative monovalent ion such as halogen; and A represents the residue of a salt of heparin after removal of the positive ion. The articles advantageously exhibit low toxicity and excellent blood compatibility when used for purposes which bring them into contact with whole blood for prolonged periods of time.
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Citations
13 Claims
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1. In a method for reducing the thrombogenicity of a solid polymeric resin, which comprises absorbing a quaternary ammonium salt on the surface of the resin and then contacting the surface with the absorbed salt, with a solution of heparin, the improvement which comprises;
- employing as said solution one containing a concentration of heparin within the range of from about 5 percent by weight to saturation.
- View Dependent Claims (2, 3, 4, 5, 6)
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7. An article for use in association with whole blood, which comprises;
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a solid, polymeric resin substrate; and a compound of the formula;
##STR6## wherein R1 is alkyl of 12 to 18 carbon atoms, inclusive;
R2, R3 and R4 are each independently selected from the group consisting of hydrogen and lower alkyl; and
A represents the negative ion of a salt of heparin, affixed to said substrate in a proportion of at least 6.61 μ
g of heparin per cm2 of the substrate surface. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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Specification