Glass support coated with synthetic polymer for bioprocess
First Claim
1. Device for use in a bioprocess, comprising:
- (a) transparent glass solid support means insoluble in a solvent solution, selected from the group consisting of water and organic solvent solutions which solid support means is coated with organic-solvent based synthetic polymeric film meansand(b) one or more functional biomaterials adsorbed or covalently bonded to said polymeric films.
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Abstract
A new and useful process is disclosed for manufacturing a device for use in a bioprocess, comprising: (a) providing solid support means insoluble in water or organic solvent solutions; (b) coating said solid support means with organic-solvent based polymeric film means capable of applying one or more biomaterials; and (c) adsorbing or covalently bonding at least one functional biomaterial to said polymeric film means. The polymeric film means, for example, can be used to coat antigens, antibodies, haptens, enzymes, living bacteria, yeasts, etc. (i.e., biomaterials) to a glass (or other) support material, e.g., a glass tube, with surprising retention of the biomaterial'"'"'s essential characteristic properties. The solid support means include but are not limited to those comprising glass, ceramics, metals, polymers and woods. The device of the invention is particularly useful in various immunoassays using a solid support for separation of phases.
144 Citations
15 Claims
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1. Device for use in a bioprocess, comprising:
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(a) transparent glass solid support means insoluble in a solvent solution, selected from the group consisting of water and organic solvent solutions which solid support means is coated with organic-solvent based synthetic polymeric film means and (b) one or more functional biomaterials adsorbed or covalently bonded to said polymeric films. - View Dependent Claims (2, 3)
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4. Process for manufacturing of a device for use in a bioprocess, comprising:
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(a) providing a transparent glass solid support means insoluble in water or organic solvent solutions; (b) coating said solid support means with organic-solvent-based synthetic polymeric film means; and (c) absorbing or covalently bonding at least one functional biomaterial to said polymeric film means. - View Dependent Claims (5, 6)
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7. Bioprocess using a device containing at least one functional biomaterial, the improvement wherein the device comprises:
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(a) transparent glass solid support means insoluble in a solvent selected from the group consisting of water and organic solvent solutions, which solid support means is coated with organic-solvent based synthetic polymeric film means; and (b) one or more functional biomaterials adsorbed or covalently bonded to said polymeric films. - View Dependent Claims (8, 9)
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10. Process for manufacture of a device for use in a bioprocess, comprising:
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(a) providing transparent glass solid support means insoluble in water or organic solvent solutions; (b) heating an organic-solvent-based, film-forming synthetic polymeric suspension from about 20°
C. to about 100°
C.;(c) coating said solid support means with said heated aqueous-solvent polymeric suspension; (d) drying the coated solid support means to remove any organic solvent to form a polymeric film on said solid support means; (e) heating the solid support means having said film from about 20°
C. to about 200°
C. for a time sufficient to cure said film;(f) cooling the solid support means having said cured film to a temperature suitable for applying one or more functional biomaterials to said cured film; and (g) adsorbing or covalently bonding at least one functional biomaterial to said polymeric film means. - View Dependent Claims (11, 12, 13, 14, 15)
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Specification