Carrier base material for prolonged release therapeutic compositions

• US 4,357,469 A
• Filed: 06/29/1981
• Issued: 11/02/1982
• Est. Priority Date: 06/14/1979
• Status: Expired due to Term

• Current Assignee: Forest Laboratories Incorporated (Abbvie Incorporated)
• Original Assignee: Forest Laboratories Incorporated (Abbvie Incorporated)
• Inventors: Schor, Joseph M.
• Primary Examiner(s): Griffin, Ronald W.
• Application Number:
  US06/278,568
• Time in Patent Office: 491 Days
• Field of Search: 536/85, 536/87, 536/91, 106/169, 106/171, 106/197 R, 106/197 C
• US Class Current: 536/91
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A carrier base material adapted to be combined with a therapeutically active medicament and shaped and compressed to form a sustained release therapeutic composition having a long-lasting, slow and regular incremental release of the medicament upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and either up to 30% ethylcellulose or 30% sodium carboxymethylcellulose or both, and wherein the carrier base material has been subjected to hydrolysis and oxidation successively or concurrently until the carbonyl content ranges from 0.2-3.0 grams/100 grams, the carboxyl content ranges from 0.60-2.60 grams/100 grams and the moisture content is in the range of 0.5-3.9%.

Claims

1. A carrier base material adapted to be combined with a therapeutically active medicament and shaped and compressed to form a sustained release therapeutic composition having a longlasting, slow and regular incremental release of the medicament upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and up to 30% ethylcellulose or 30% sodium carboxymethylcellulose or both, and wherein the carrier base material has been subjected to hydrolysis and oxidation successively or concurrently until the carbonyl content ranges from 0.2-3.0 grams/100 grams, the carboxyl content ranges from 0.60-2.60 grams/100 grams and the moisture content is in the range of 0.5-3.9%.

2. A carrier base material according to claim 1 in which has been incorporated 0.1-1.0%, based on the weight of the carrier base, of a reducing agent which prevents undesired further oxidation.

3. A carrier base material according to claim 2 wherein the reducing agent is selected from the group consisting of ascorbyl stearate, ascorbyl palmitate and sodium metabisulfite.