Maytansinoid compound

• US 4,362,663 A
• Filed: 09/17/1980
• Issued: 12/07/1982
• Est. Priority Date: 09/21/1979
• Status: Expired due to Term

• Current Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Original Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Kida, Makoto, Nakahama, Kazuo, Izawa, Motowo
• Primary Examiner(s): Bond, Robert T.
• Application Number:
  US06/188,239
• Time in Patent Office: 811 Days
• Field of Search: 260/239.3 P, 260/239.3 T
• US Class Current: 540/462
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 33/02 Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C12N 1/205 Bacterial isolates
• CPC Class Codes: C12P 17/188 Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms ergot-alcaloids C12P17/183
• CPC Class Codes: C12R 2001/14 Chainia
• CPC Class Codes: C12R 2001/465 Streptomyces
• CPC Class Codes: Y10S 435/872 Nocardia

Abstract

Antibiotic C-15003 PND of the formula: ##STR1## wherein R is H or alkanoyl containing not more than 5 carbon atoms is produced by contacting a maytansinoid compound with a culture broth, inclusive of a processed matter derived therefrom, of a microorganism belonging to one of the genera Streptomyces and Chainia which is able to transform said maytansinoid compound into Antibiotic C-15003 PND.

Antibiotic C-15003 PND is useful as antitumor, antifungal or antiprotozoal agent.

Claims

1. A compound of the formula:

##STR14##