Magnetic field hemostasis

• US 4,364,377 A
• Filed: 02/02/1981
• Issued: 12/21/1982
• Est. Priority Date: 02/02/1979
• Status: Expired due to Fees

• Current Assignee: Science Park Corporation
• Original Assignee: Science Park Corporation
• Inventors: Smith, Frederic W.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/230,621
• Time in Patent Office: 687 Days
• Field of Search: 128/1.3, 128/1.5, 128/325
• US Class Current: 600/12
• CPC Class Codes: A61B 17/12 for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord specially adapted for vas deferens or fallopian tubes A61F6/20; materials for ligaturing blood vessels A61L17/00
• CPC Class Codes: A61B 90/00 Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges protective face masks A41D13/11; surgeon's or patient's gowns or dresses A41D13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M1/00
• CPC Class Codes: A61K 33/26 Iron; Compounds thereof
• CPC Class Codes: A61K 9/5094 Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding

Abstract

Disclosed is a method for staunching blood flow from an acutely bleeding gastrointestinal lesion. The method comprises introducing, into the gastrointestinal tract, a tamponading mass having ferromagnetic properties. A suitable tamponading mass is a mixture of finely divided iron particles and vegetable oil which may be introduced through an endoscopic catheter. Once in the gastrointestinal tract, the tamponading mass is moved as necessary to cover and press upon the bleeding lesion by a magnetic field generated outside the body, e.g. by an electromagnet. The positioning is under the direct visual control of the endoscopist.

Claims

1. Process for staunching bleeding at a lesion located in a comparatively large body cavity such as the gastrointestinal tract comprising the steps of:

(1) providing a liquid tamponading mass of a large volume that covers said lesion, said liquid mass being formed of ferromagnetic particles suspended in said large volume of a viscous liquid;

(2) introducing said mass into the gastrointestinal tract; and

(3) biasing said mass to cover and to press upon a bleeding lesion within said gastrointestinal tract by externally generated magnetic field means that acts upon said ferromagnetic particles, said biasing acting to hold said liquid mass in position over said lesion and to staunch the bleeding at said lesion.

2. The process of claim 1 wherein said particles are iron and said liquid is oil.

3. The process of claim 1 wherein said tamponading mass is encased within a biologically inert covering material.

4. The process of claim 1 wherein said introducing is accomplished with an endoscopic catheter.

5. The process of claim 1 wherein said externally generated magnetic field means comprises an electromagnet.

6. The process of claim 1 wherein said externally generated magnetic field means comprises a permanent magnet.

7. The process of claim 1 wherein said tamponading mass includes at least one blood clotting factor.

8. The process of claim 7 wherein said clotting factor is thrombin.

9. The process of claim 1 wherein said tamponading mass includes tissue cement.

10. The process of claim 1 wherein said tamponading mass includes a chemical cautery agent.

11. The process of claim 1 wherein said particles are iron oxide.

12. The process of claim 1 wherein said particles are iron covered with silicone rubber.

13. The process of claim 1 wherein said viscous liquid is starch gel.

14. The process of claim 1 wherein said viscous liquid is liquid silicone.

15. The process of claim 1 wherein said viscous liquid is glycerine.

16. The process of claim 1 wherein said viscous liquid is a glycerine-based gel.

17. Process for stopping bleeding at a lesion located in a comparatively large body cavity such as the gastrointestinal tract comprising the steps of:

(1) providing a liquid tamponading mass of a large volume that covers said lesion, said liquid mass being formed of a mixture of finely divided iron particles suspended in said volume of oil;

(2) introducing said mass into the gastrointestinal tract through an endoscopic catheter;

(3) moving said mass to cover said lesion by external electromagnet means; and

(4) biasing said mass to press upon said lesion by electromagnet means to stop the bleeding.

18. The process of claim 17 wherein said tamponading mass includes thrombin.