Nalbuphine-narcotic analgesic composition and method of producing analgesia
First Claim
1. A method of producing analgesia in a mammal comprising administering to a mammal an analgesic dose containing about 1-100 mg of nalbuphine or a pharmaceutically suitable salt thereof and an analgesic dose containing a narcotic analgesic selected from:
- (a) about 1-100 mg of morphine or a pharmaceutically suitable salt thereof;
(b) about 0.1-20 mg of oxymorphone or a pharmaceutically suitable salt thereof;
(c) about 0.5-50 mg of oxycodone or a pharmaceutically suitable salt thereof;
or(d) about 0.1-20 mg of hydromorphone or a pharmaceutically suitable salt thereof.
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Abstract
A narcotic analgesic composition particularly in oral dosage form is provided which provides excellent analgesia in a mammal while reducing or eliminating the respiratory depression and euphoria usually associated with narcotic analgesics. The composition comprises an analgesic effective amount of a narcotic analgesic or salt thereof and an analgesic effective amount of nalbuphine or a salt thereof.
A method of producing analgesia in a mammal is also provided, this method comprises administering to a mammal parenterally or orally an analgesic effective amount of a narcotic analgesic or salt thereof and an analgesic effective amount of nalbuphine or a salt thereof. Administration of the narcotic analgesic and nalbuphine can be either sequentially or simultaneously.
53 Citations
10 Claims
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1. A method of producing analgesia in a mammal comprising administering to a mammal an analgesic dose containing about 1-100 mg of nalbuphine or a pharmaceutically suitable salt thereof and an analgesic dose containing a narcotic analgesic selected from:
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(a) about 1-100 mg of morphine or a pharmaceutically suitable salt thereof; (b) about 0.1-20 mg of oxymorphone or a pharmaceutically suitable salt thereof; (c) about 0.5-50 mg of oxycodone or a pharmaceutically suitable salt thereof;
or(d) about 0.1-20 mg of hydromorphone or a pharmaceutically suitable salt thereof. - View Dependent Claims (2, 3, 4)
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5. An analgesic composition which comprises per analgesic dose of the composition about 1-100 mg of nalbuphine or a pharmaceutically suitable salt thereof and:
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(a) about 1-100 mg of morphine or a pharmaceutically suitable salt thereof; (b) about 0.1-20 mg of oxymorphone or a pharmaceutically suitable salt thereof; (c) about 0.5-50 mg of oxycodone or a pharmaceutically suitable salt thereof;
or(d) about 0.1-20 mg of hydromorphone or a pharmaceutically suitable salt thereof. - View Dependent Claims (6, 7, 8, 9, 10)
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Specification