Dispenser powered by cross-linked hydrophilic polymer grafted to hydrophilic polymer

• US 4,367,741 A
• Filed: 12/22/1980
• Issued: 01/11/1983
• Est. Priority Date: 12/22/1980
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Michaels, Alan S.
• Primary Examiner(s): Rosenbaum, C. Fred
• Application Number:
  US06/218,729
• Time in Patent Office: 750 Days
• Field of Search: 128/260, 128/261, 222/95, 222/386.5
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61L 9/042 with the help of a macromolecular compound as a carrier or diluent A61L9/048 takes precedence
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispenser is disclosed comprising a housing formed of a laminate of a cross-linked hydrophilic polymer layer grafted to a noncross-linked hydrophilic layer. The housing surrounds a container made of an elastomeric material and the container has an outlet through the housing to the exterior of the dispenser.

Claims

1. A dispenser comprising:

a housing formed of a laminate comprising a layer of a cross-linked hydrophilic polymer grafted to a layer of a noncross-linked hydrophilic polymer;

a container within the housing, said container made of a material changeable from a storing capacity to a substantially emptied capacity over time;

an outlet mean in the container that communicates with the container and the exterior of the dispenser, and wherein, when the dispenser is in operation in the environment of use, the dispenser releases its contents in response to the laminate absorbing fluid from the environment and expanding, thereby exerting pressure on the container which changes from a storing capacity to a substantially emptied capacity and dispenses its contents through the outlet means from the dispenser.

2. The dispenser of claim 1 wherein the container is charged with a fluid.

3. The dispenser of claim 1 wherein the container is charged with a beneficial agent.

4. The dispenser of claim 1 wherein the cross-linked hydrophilic polymer is formed from a mixture of a monoethylenically unsaturated monomer and a cross-linking monomer containing at least two ethylenic double bonds.

5. The dispenser of claim 1 wherein the hydrophilic polymer is homogenous and a noncross-linked polymer, and is formed from a monoethylenically unsaturated monomer.

6. The dispenser of claim 1 wherein the container contains a drug, which drug is present in solution, in semi-solid, or in a thixotropic formulation.

7. The dispenser of claim 1 wherein the dispenser is sized, shaped and adapted for oral use.

8. The dispenser of claim 1 wherein the dispenser is sized, shaped and adapted for vaginal use.

9. The dispenser of claim 1 wherein the dispenser is sized, shaped and adapted for ano-rectal use.

10. The dispenser of claim 1 wherein the dispenser is sized, shaped and adapted for use as an implant.

11. The dispenser of claim 1 wherein the container is made of a member selected from the group consisting of natural rubber, gutta percha, cyclized rubber, silicone rubber, isoprene rubber, butadiene rubber, styrenebutadiene rubber, nitrile rubber, chloroprene rubber, ethylene-butylene rubber, and butyl rubber.

12. The dispenser of claim 1 wherein the container is connected to a conduit leading to a distant site.