Deaerating liquid

• US 4,371,385 A
• Filed: 04/28/1981
• Issued: 02/01/1983
• Est. Priority Date: 04/28/1981
• Status: Expired due to Term

• Current Assignee: Gambro, Inc. (DaVita Incorporated)
• Original Assignee: COBE Laboratories Incorporated (Terumo Corporation)
• Inventors: Johnson, Steven H.
• Primary Examiner(s): Adee, John
• Application Number:
  US06/258,423
• Time in Patent Office: 644 Days
• Field of Search: 210/96.2, 210/321.2, 55/159, 55/190, 55/200, 55/201, 55/202, 55/206
• US Class Current: 96/196
• CPC Class Codes: A61M 1/1658 Degasification
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/6081 Colour codes
• CPC Class Codes: B01D 19/0063 Regulation, control including valves and floats for construction and details of valves F16K
• CPC Class Codes: B01D 2311/02 Specific process operations before starting the membrane separation process
• CPC Class Codes: B01D 2311/2657 Deaeration
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation
• CPC Class Codes: Y10S 210/929 Hemoultrafiltrate volume measurement or control processes

Abstract

Liquid deaeration apparatus having a deaeration chamber, a positive displacement pump downstream of the deaeration chamber, a first flow restrictor upstream of the deaeration chamber, a low pressure sink connected to an air outlet of the deaeration chamber, and a second flow restrictor between the pump and the liquid outlet of the deaeration chamber to raise the pressure at the liquid outlet above that at the air outlet to cause volatilized gas to be removed via the air outlet of the deaeration chamber.

Claims

1. Apparatus for deaerating liquid supplied to a dialyzer comprising

first flow restriction means in a source supply line connected to a source of liquid to limit the flow rate through said line,

first deaeration chamber means having a liquid outlet, a liquid inlet connected to said source supply line downstream of said first flow restriction means, and an air outlet located above said liquid inlet and said liquid outlet,

a first positive displacement pump having an inlet connected to said liquid outlet of said deaeration chamber means, so that said deaeration chamber means is between said pump and said first flow restriction means, and an outlet connected to a dialyzer supply line and capable of pumping at a flow rate higher than the flow rate permitted by said first flow restriction means to lower the pressure of the liquid between said first pump and said first flow restriction means and cause volatilization of gases dissolved therein,

low pressure sink means connected to said air outlet, and

second flow restriction means connected between said liquid outlet of said deaeration chamber means and said first pump to raise the pressure at said liquid outlet to a level greater than that at said air outlet to cause volatilized gas collected within said chamber to flow through said air outlet and not through said liquid outlet.

2. The apparatus of claim 1 further comprising a liquid heater located on said supply line upstream of said first deaeration chamber means.

3. The apparatus of claim 2 further comprising nucleation chamber means located on said supply line downstream of said heater and between said first flow restriction means and said first deaeration chamber means,

said nucleation chamber means containing in it first material providing sites for bubble formation.

4. The apparatus of claim 3 further comprising second material in said first deaeration chamber means, said second material providing sites at which bubbles will be detained and will increase in size.

5. The apparatus of claim 4 further comprising second deaeration chamber means having a liquid inlet connected to the outlet of said first pump, said second chamber means including an air outlet connected to said low pressure sink and a liquid outlet.

6. The apparatus of claim 1 further comprising second deaeration chamber means having a liquid inlet connected to the outlet of said first pump, said second chamber means including an air outlet connected to said low pressure sink and a liquid outlet.

7. The apparatus of claim 4 wherein said low pressure sink is a second positive displacement pump.

8. The apparatus of claim 5, 6, or 7 wherein said liquid is water and further comprising

a third deaeration chamber means having a liquid inlet, a liquid outlet, and an air outlet connected to said low pressure sink,

a supply line for concentrated dialysate solution connected at a junction to a supply line from said outlet of said second deaeration chamber means, and

a dialysate line for the combined water and concentrated dialysate solution connecting said junction to the liquid inlet of said third deaeration chamber means.

9. The apparatus of claim 7 wherein said liquid is water and further comprising

a third deaeration chamber means having a liquid inlet, a liquid outlet, and an air outlet connected to said low pressure sink,

a supply line for concentrated dialysate solution connected at a junction to a supply line from said outlet of said second deaeration chamber means,

a dialysate line for the combined water and concentrated dialysate solution connecting said junction to the liquid inlet of said third deaeration chamber means,

a dialyzer, the dialysate inlet of which is connected to the liquid outlet of said third deaeration chamber, and

a dialysate return line connecting the dialysate outlet of said dialyzer to the inlet of said second pump.