Treatment of acne and skin disorders and compositions therefor

• US 4,372,296 A
• Filed: 11/26/1980
• Issued: 02/08/1983
• Est. Priority Date: 11/26/1980
• Status: Expired due to Term

• Current Assignee: Mostafa S. Fahim
• Original Assignee: Mostafa S. Fahim
• Inventors: Fahim, Mostafa S.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Swisher, Nancy A. B.
• Application Number:
  US06/210,370
• Time in Patent Office: 804 Days
• Field of Search: 128/24 A, 128/1 R
• US Class Current: 601/2
• CPC Class Codes: A61K 2800/81 Preparation or application process involves irradiation
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A composition is disclosed which when topically applied is effective in the treatment of acne and skin disorders. While the etiology of the treatment is complex, it is believed that the composition reduces the rate of sebum secretion, inhibits the formation of keratin and fatty acids in the pilosebaceous ducts and is antimicrobial to the bacteria normally found in said ducts. The treatment is accomplished quicker and stimulates the production of collagen in the healing of scars if the composition is sonicated into the affected area with ultrasonic vibrations.

Claims

1. A method for treating acne comprising topically administering with ultrasonic vibrations at a frequency between 1000 KHZ and 3000 KHZ and at a power level between 0.5 and 3.0 watts per sq. cm. to acne affected skin an effective amount of a composition comprising from about 1.0 to about 4.0 percent by weight of zinc sulfate and from about 2.0 to about 6.0 percent by weight of ascorbic acid in a pharmaceutical carrier which is an effective coupling agent for ultrasonic vibrations and which does not inactivate the pharmacological activity of the zinc salt or ascorbic acid whereby said composition effectively retards the rate of sebum secretion in the treated area and stimulates the production of collagen.

2. The method of claim 1 wherein the ultrasonic vibrations are pulsed and finely focused on the acne affected skin being treated.

3. The method of claim 1 wherein the ultrasonic vibrations are continuous and diffusely focused on the acne affected skin being treated.