Equipment sets having a combined air barrier and liquid sequencing device for the sequential administration of medical liquids at dual flow rates

• US 4,372,306 A
• Filed: 01/26/1981
• Issued: 02/08/1983
• Est. Priority Date: 02/28/1979
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Muetterties, Andrew J., Genese, Joseph N.
• Primary Examiner(s): Truluck, Dalton L.
• Application Number:
  US06/228,632
• Time in Patent Office: 743 Days
• Field of Search: 128/214 R, 128/214 G, 128/214.2, 128/227, 137/173, 137/183, 137/198, 137/199, 137/113, 55/159, 222/145
• US Class Current: 604/122
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/36 with means for eliminating or preventing injection or infusion of air into body dialysis systems, blood oxygenators A61M1/14; haemofiltration equipment A61M1/34; automatic tube cut-off A61M39/281
• CPC Class Codes: Y10T 137/2569 Control by depletion of source

Abstract

Equipment sets for the sequential administration of medical liquids allow primary liquid to be administered at a flow rate independent of the flow rate of a secondary liquid. The sets include a combined air barrier and liquid sequencing device to prevent the inadvertent administration of air when secondary liquid is depleted. The device also prevents the flow of primary liquid when secondary liquid is being dispensed.

Claims

1. A gravitational flow system for the sequential administration of medical liquids to a patient comprising:

a primary container suspended in space for containing a primary medical liquid;

a primary tube having its distal end in fluid communication with said primary container;

a secondary container suspended in space at a height greater than that of said primary container for containing a secondary medical liquid;

a secondary tube having its distal end in fluid communication with said secondary container;

a common tube having its distal end in fluid communication with the proximal ends of said primary and secondary tubes and its proximal end open for the flow of liquid therethrough to form a primary liquid path comprising said primary tube and said common tube and a secondary liquid flow path comprising said secondary tube and said common tube;

secondary flow control means in said secondary liquid flow path for adjusting the flow rate of said secondary liquid therethrough;

primary flow control means on said primary tube for adjusting the flow of said primary liquid through said primary liquid flow path at a rate independent of the flow rate of said secondary liquid through said secondary liquid flow path;

a combined air barrier and liquid sequencing valve interposed in said primary and secondary flow paths which allows primary liquid to flow from said primary container whenever the height of said primary liquid is greater than or equal to the height of said secondary liquid in said system and which prevents primary liquid from flowing from said primary container whenever the height of said primary liquid is less than the height of said secondary liquid in said system;

said combined air barrier and liquid sequencing valve comprising a housing divided into two or more parallel chambers, at the top thereof a first chamber in said housing having an inlet port incorporated therein for the passage of primary liquid into said first chamber, said inlet port having a hydrophilic membrane incorporated therein and covered thereby, and an outlet port incorporated therein for the passage of liquid from said first chamber, said outlet port from said first chamber including a hydrophilic membrane incorporated therein and covered thereby for preventing the passage of air from said first chamber through said outlet port when said hydrophilic membrane is moistened;

a second chamber in said housing having an inlet port to said second chamber at the top thereof for the admission of secondary liquid therein and an outlet port from said second chamber for the passage of secondary liquid therefrom, said outlet port from said second chamber including a second hydrophilic membrane incorporated therein for preventing the passage of air therethrough; and

an air capturing pocket proximate said hydrophilic membrane covering said inlet port to said first chamber, said air capturing pocket comprising the area beneath said hydrophilic membrane covering said inlet port to said first chamber, the sides of said air capturing pocket being defined by the side walls of said first chamber proximate the top of said first chamber, said air capturing pocket being constructed and arranged for the reception of residual air within said first chamber proximate said hydrophilic membrane when said secondary liquid is dispensed into said second chamber whereby the flow of said primary liquid is interrupted for so long as the pressure of said secondary liquid is greater than that of said primary liquid.

3. The combined air barrier and liquid sequencing valve defined in claim 1 or 2 and further including a reservoir incorporated therein for the reception of secondary liquid within said second chamber, said reservoir being constructed and arranged so as to overflow said secondary liquid into said first chamber thereby filling said first chamber and entrapping residual air within said air capturing pocket.

4. The valve defined in claim 1, wherein said inlet port to said first chamber is positioned proximate the top thereof and said inlet and outlet ports to said second chamber are respectively positioned proximate the top and side thereof.

5. The valve defined in claim 3, wherein said reservoir is integrally formed as a portion of said second chamber.

6. The valve defined in claim 1 or 2, wherein said first chamber further includes a closable air vent.

7. The valve defined in claim 6, wherein said air vent is covered by a hydrophobic membrane.

8. The valve defined in claim 1 or 3 wherein said air capturing pocket comprises a raised tubular portion incorporated in said first chamber, said hydrophilic membrane being incorporated in said raised tubular portion whereby air may be entrapped within said raised tubular portion during dispensing of secondary liquid due to the relatively greater partial pressure of said secondary liquid as compared to the partial pressure of said primary liquid thereby resulting in a greater partial pressure against the ventral surface of said hydrophilic membrane as opposed to the dorsal surface.

9. The combined air barrier and liquid sequencing valve defined in claim 1 or 2 wherein said second chamber further includes a closable air vent.

10. The combined air barrier and liquid sequencing valve defined in claim 9 wherein said air vent is positioned proximate the top of said housing and is covered by a hydrophobic membrane thereby preventing the passage of liquid therefrom.

11. The valve defined in claim 1 or 2 wherein said second chamber further comprises a reservoir incorporated therein, said reservoir comprising a hydrophilic membrane disposed across and selectively sealing said second chamber below said outlet, said hydrophilic membrane constructed and arranged to direct a portion of said secondary liquid into said first chamber until said first chamber is substantially filled, whereby said primary liquid flow is halted and said secondary liquid may pass through said outlet ports of said first and second chambers.

2. A combined air barrier and liquid sequencing valve for the sequential administration of a primary liquid and a secondary liquid comprising:

a housing divided into two or more parallel chambers, a first chamber in said housing having an inlet port at the top thereof incorporated therein for the passage of primary liquid into said first chamber, said inlet port including a hydrophilic membrane incorporated therein and covered thereby, and an outlet port incorporated therein for the passage of said primary liquid from said first chamber, said outlet port from said first chamber includingg a hydrophilic membrane incorporated therein and covered thereby for preventing the passage of air from said first chamber through said outlet port when said hydrophilic membrane is moistened;

a second chamber in said housing having an inlet port for the admission of secondary liquid therein and an outlet port from said second chamber for the passage of secondary liquid therefrom, said outlet port from said second chamber including a second hydrophilic membrane incorporated therein for preventing the passage of air therethrough; and

an air capturing pocket proximate said hydrophilic membrane covering said inlet port to said first chamber, said air capturing pocket comprising the area beneath said hydrophilic membrane covering said inlet port to said first chamber, the sides of said air capturing pocket being defined by the side walls of said first chamber, said air capturing pocket being constructed and arranged for the reception of residual air within said first chamber proximate said hydrophilic membrane when said secondary liquid is dispensed into said second chamber whereby the flow of said primary liquid is interrupted for so long as the pressure of said secondary liquid is greater than that of said primary liquid.