Antigen compounds
First Claim
1. An antigen compound useful in the production of an antigen conjugate compound for producing relatively large titers of antibodies specific thereto, which compound comprises a killed strain of B. pertussis mutant strain NRRL B-11, 232 coupled to one reactive NCO site of a diisocyanate-coupling agent leaving the other reactive NCO site adapted to be coupled to another antigen.
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Abstract
Antigens are provided which induce relatively large titers of antibodies. These antigens, which may comprise certain strains of microorganisms or a plant extract, can be conjugated to a second antigen by means of an organic coupling agent. The primary antigens of the invention, when chemically coupled to a secondary antigen function as immunostimulant adjuvants. When tumor cells are the secondary antigens, a means for immunotherapeutic treatment of cancer is provided.
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Citations
4 Claims
- 1. An antigen compound useful in the production of an antigen conjugate compound for producing relatively large titers of antibodies specific thereto, which compound comprises a killed strain of B. pertussis mutant strain NRRL B-11, 232 coupled to one reactive NCO site of a diisocyanate-coupling agent leaving the other reactive NCO site adapted to be coupled to another antigen.
Specification