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Solid-phase synthesis of polynucleotides

  • US 4,373,071 A
  • Filed: 04/30/1981
  • Issued: 02/08/1983
  • Est. Priority Date: 04/30/1981
  • Status: Expired due to Term
First Claim
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1. In a method of creating polynucleotides, the following steps:

  • treating a resin with potassium phthalimide to obtain a phthalimidomethyl-resin,converting the phthalimidomethyl-resin into an amino resin with hydrazine, andcombining the amino-resin with an activated ester of a nucleoside to obtain an amino-bonded dimethoxytrityl resin.

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