Composite wound dressing

• US 4,373,519 A
• Filed: 06/26/1981
• Issued: 02/15/1983
• Est. Priority Date: 06/26/1981
• Status: Expired due to Term

• Current Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Stoesz, James D., Errede, Louis A., Winter, deceased, George D.
• Primary Examiner(s): Rosenbaum, C. Fred
• Application Number:
  US06/277,990
• Time in Patent Office: 599 Days
• Field of Search: 128/155-156, 128/284, 128/287, 128/290 R, 128/296
• US Class Current: 602/43
• CPC Class Codes: A61F 13/01046 Air-vapor permeability
• CPC Class Codes: A61F 13/069 Decubitus ulcer bandages
• CPC Class Codes: A61F 13/8405 Additives, e.g. for odour, disinfectant or pH control
• CPC Class Codes: A61F 2013/00157 for burns or skin transplants A61F2013/00187 takes precedence; not adhering to the wound A61F2013/00217
• CPC Class Codes: A61F 2013/00217 not adhering to the wound
• CPC Class Codes: A61F 2013/00246 in a special way pervious to air or vapours
• CPC Class Codes: A61F 2013/00263 vapour permeability >500 g/m2/24h
• CPC Class Codes: A61F 2013/00463 haemostatic
• CPC Class Codes: A61F 2013/00472 with chemical means
• CPC Class Codes: A61F 2013/00519 for treating burn
• CPC Class Codes: A61F 2013/00876 vapour permeability >500 g/mg/24h
• CPC Class Codes: A61F 2013/0091 with disinfecting or anaesthetics means, e.g. anti-mycrobic
• CPC Class Codes: A61F 2013/00931 chitin
• CPC Class Codes: A61F 2013/530481 having superabsorbent materials, i.e. highly absorbent polymer gel materials
• CPC Class Codes: A61F 2013/530496 being fixed to fibres
• CPC Class Codes: A61L 15/24 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: Y10S 128/21 Silicone

Abstract

A composite wound dressing, optionally having controlled permeability, is highly absorbent toward blood and exudate and comprises a polytetrafluoroethylene fibril matrix, hydrophilic absorptive particles enmeshed in the matrix, and, optionally, a partially occlusive film coated on one surface of the matrix.

Claims

1. A composite wound-dressing which is a sheet material, comprising:

(a) a polytetrafluoroethylene fibril matrix,

(b) 0.5 to 10 parts of hydrophilic absorptive particles per part of PTFE by weight enmeshed in said matrix, the absorptive particles having absorptive capacity greater than 0.5 grams of water per gram of dry particles, and

(c) a partially occlusive film coated on one surface of said matrix,

wherein substantially all of said hydrophilic absorptive particles are unavailable for sloughing.

2. The composite wound-dressing according to claim 1 wherein said hydrophilic absorbent particles are alginic acid, polyacrylatecellulose graft copolymer, collagen, chitin, chitosan, dextran, clay, casein, zein, carboxymethyldextran, starch, hydroxyethyl starch, hydrolyzed polyacrylonitrile, starch-methacrylonitrile polymer, polyacrylamide, hydrolyzed polyacrylamide, cellulose, carboxymethylcellulose or derivatives or mixtures thereof.

3. The composite wound-dressing according to claim 1 wherein said hydrophilic absorptive particles are particles of a crosslinked dextran derivative.

4. The composite wound-dressing according to claim 1 wherein said hydrophilic absorptive particles are admixed with inert diluent particles.

5. The composite wound-dressing according to claim 4 wherein said inert diluent particles are selected from polyethylene, polypropylene, polystyrene, kaolin, talc, silica, bentonite, and vermiculite.

6. The composite wound-dressing according to claim 4 wherein said particles comprise 40-90% of the weight of the said composite wound-dressing.

7. The composite wound-dressing according to claim 4 wherein said particles comprise about 80 to 90% of the weight of said composite wound-dressing.

8. The composite wound-dressing according to claim 1 wherein said hydrophilic absorbent particles range in size from about 0.1 to 300 micrometers.

9. The composite wound-dressing according to claim 1 wherein said hydrophilic absorbent particles range in size from about 1.0 to 80 micrometers.

10. The composite wound-dressing according to claim 1 wherein said fibril matrix comprises fibrils having a thickness in the range of about 0.025 to 0.5 micrometers.

11. The composite wound-dressing according to claim 1 wherein said partially occlusive film is a polymer of silicone, urethane, or acrylate.

12. The composite wound-dressing according to claim 1 wherein the rate of transmission of moisture through said dressing is in the range of about 240 to 2400 g/m² /24 hrs, at 37°

C. and 75% relative humidity.

13. The composite wound-dressing according to claim 1 wherein said dressing has a thickness in the range of 0.1 to 10 mm.

14. The composite wound-dressing according to claim 1 wherein said partially occlusive film has a thickness in the range of 2 to 200 micrometers.

15. The composite wound-dressing according to claim 1 further comprising medicaments selected from antibacterial agents, antifungal agents, hemostatic agents, and wound-healing agents.

16. A method of treating a wound comprising applying to said wound a composite wound-dressing which is a sheet material comprising:

(a) a polytetrafluoroethylene fibril matrix; and

(b) 0.5 to 10 parts of hydrophilic absorptive particles per part of PTFE by weight enmeshed in said matrix, the absorptive particles having absorptive capacity greater than 0.5 grams of water per gram of dry particles,

wherein substantially all of said hydrophilic absorptive particles are unavailable for sloughing.

17. The method of treating a wound according to claim 16 wherein said wound-dressing further comprises a partially occlusive film coated on one surface of said matrix.

18. The method of treating a wound according to claim 16 wherein said wound-dressing further comprises medicaments selected from antibacterial agents, antifungal agents, hemostatic agents, and wound-healing agents.