Control of mastitis

• US 4,376,787 A
• Filed: 12/03/1979
• Issued: 03/15/1983
• Est. Priority Date: 12/03/1979
• Status: Expired due to Term

• Current Assignee: Ecolab, Inc.
• Original Assignee: Ecolab, Inc.
• Inventors: Lentsch, Steven E., Schmidt, William
• Primary Examiner(s): Rosen, Sam
• Application Number:
  US06/099,735
• Time in Patent Office: 1,198 Days
• Field of Search: 424/303, 424/315, 424/225, 424/224, 424/223, 252/DIG. 5
• US Class Current: 514/576
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 41/04 Sulfonic acids; Derivatives thereof
• CPC Class Codes: A01N 57/12 containing acyclic or cycloaliphatic radicals
• CPC Class Codes: A01N 57/14 containing aromatic radicals
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/66 Phosphorus compounds
• CPC Class Codes: A61K 9/0041 Mammary glands, e.g. breasts, udder; Intramammary administration
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A mastitis controlling method and composition based upon anionic surfactants of the formula

R--AO.sub.x.sup.- M.sup.+

which generally includes organic sulfonates, sulfonic acids, phosphonates and phosphates, the composition being maintained in a pH range of 2.0 to 5.0 (preferably 2.1 to 4.0, and most preferably 2.5 to 3.5). Rapid kill of mastitis-causing gram positive and gram negative microorganisms is achieved in the practice of the instant method.

Claims

1. A method for killing mastitis-causing gram negative organisms including Pseudomonas aeruginosa, Escherichia coli, or Klebsiella pneumoniae or gram positive organisms including Staphylococcus auereus on an animal'"'"'s teats comprising the step of treating the teats of the animal with an thickened aqueous medium formulated to ensure a contact time between the teats and the medium of 15 seconds to 15 minutes, the medium comprising:

(a) anionic surfactant of the formula

space="preserve" listing-type="equation">RAO.sub.x.sup.-.sub.M.sup.+

wherein R is essentially organic, A is sulfur or phosphorus, x is 3 or 4, and M is topically acceptable cation; and

(b) a pH modifying or maintaining substance in an amount sufficient to adjust a pH of the composition to a value in the range of 2.0 to 5.0.

2. A method according to claim 1 wherein the R of the anionic surfactant is an alkyl-aryl radical.

3. A method according to claim 1 wherein the R of the anionic surfactant is linear alkyl-aryl radical.

4. A method according to claim 1 wherein R of the anionic surfactant is linear alkylbenzene radical.

5. A method according to claim 1 wherein A of the anionic surfactant is sulfur.

6. A method in accordance with claim 5 wherein x is 3.

7. A method in accordance with claim 5 wherein R is linear alkylbenzene radical.

8. A method in accordance with claim 7 wherein the anionic surfactant is sodium linear alkylbenzene sulfonate.

9. A method in accordance with claim 8 wherein the anionic surfactant is sodium dodecylbenzene sulfonate.

10. A method according to claim 1 wherein the anionic surfactant is lineaar alkylbenzene sulfonate.

11. A method according to claim 1 wherein the anionic surfactant is sodium dodecylbenzene sulfonate.

12. A method according to claim 1 wherein the pH modifying substance modifies the pH to a value in the range of 2.1 to 4.0.

13. A method according to claim 1 wherein the pH modifying substance modifies the pH of the composition in the range of 2.5 to 3.5.

14. A method according to claim 1 in which the pH modifying substance is a buffer.

15. A method according to claim 14 in which the buffer is a mixture of citric acid and sodium citrate.

16. A method according to claim 1 which further comprises a thixotrope.

17. A method according to claim 16 wherein the thixotrope is sodium carboxymethyl cellulose.

18. A method for killing mastitis-causing gram negative organisms including Pseudomonas aeruginisa, Escherichia coli, or Klebsiella pneumoniae or gram positive organisms including Staphylococcus aureus on an animals'"'"'s teats comprising the step of dipping the teats of the animal in a reservoir containing an thickened aqueous medium formulated to ensure a contact time between the teats and the medium of 15 seconds to 15 minutes, the medium comprising:

(a) anionic surfactant of the formula

space="preserve" listing-type="equation">RAO.sub.x.sup.- M.sup.+

wherein R is organic, x is 3 or 4, A is sulfur or phosphorus, and M is a topically acceptable cation; and

(b) a pH modifying or maintaining substance in an amount sufficient to adjust the pH of the composition to a value in the range of 2.0 to 5.0.

19. A method according to claim 18 wherein R is monovalent, alkyl-aryl radical.

20. A method according to claim 18 wherein R is an alkyl-benzene radical.

21. A method according to claim 18 wherein R is of the structure ##STR3## n having a value of from 9 to 18.

22. A method according to claim 21 wherein the C_n H_2n-1 structure is linear.

23. A method according to claim 21 wherein the anionic surfactant is sodium dodecylbenzene sulfonate.

24. A method according to claim 18 wherein the pH maintaining substance is a buffer.

25. A method according to claim 24 wherein buffer modifies the composition to a pH in the range of 2.1 to 4.0.

26. A method according to claim 18 wherein the buffer maintains the pH of the medium in the range of 2.5 to 3.5.

27. A method according to claim 18 wherein the mastitis-causing organisms are killed in less than 5 minutes.

28. A method according to claim 18 wherein the mastitis-causing organisms are killed in less than 30 seconds.