Audio-telemetric pressure sensing systems and methods

• US 4,378,809 A
• Filed: 06/19/1980
• Issued: 04/05/1983
• Est. Priority Date: 04/13/1978
• Status: Expired due to Term

• Current Assignee: Radionics, Inc. (Integra LifeSciences Holdings Corporation)
• Original Assignee: Eric R. Cosman
• Inventors: Cosman, Eric R.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Hanley, John C.
• Application Number:
  US06/161,098
• Time in Patent Office: 1,020 Days
• Field of Search: 128/748, 128/675, 73/701, 73/702, 73/716, 73/717
• US Class Current: 600/561
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/031 Intracranial pressure

Abstract

A differential pressure sensing device is fully implanted beneath the skin in the living body such that its pressure responsive means, such as a diaphragm means, senses the difference in pressure between an internal bodily pressure and the pressure on the skin which is just above the sensor. The sensor has a stop, or a mechanical contact means, for the diaphragm means so that the diaphragm will be pressed against the stop when an externally applied pressure on the skin equals or exceeds the internal pressure. The sensor also has a means with a detectable parameter that can be detected outside the body by external apparatus. The external apparatus also converts the parameter to an audible sound or audio signal. The parameter has a specific response when the diaphragm is near the stop position, and this response can be heard via the audio signal. Thus by increasing the externally applied pressure to the skin above the sensor and listening for the characteristic audio signal corresponding to the diaphragm being at or near the stop position, one can determine the external pressure needed to balance the internal bodily pressure, and thus measure the latter.

Claims

1. A method for detecting an in-vivo differential pressure, said method comprising the steps of:

(a) implanting beneath the skin in a living body a differential pressure sensor comprising;

(1) a flexible-diaphragm means having a first side and a second side, the differential pressure sensor being so adapted that when implanted in the living body the first side of the flexible diaphragm means is in mechanical pressure communication with a first bodily medium and the second side of said flexible diaphragm means is in mechanical pressure communication with a second bodily medium, so that changes in the difference in the pressures in said two bodily regions will cause movement of said flexible diaphragm means;

(2) means located within said differential pressure sensor and at least in part cooperatively connected to said flexible diaphragm means having a detectable characteristic response to movement of said flexible diaphragm means, said detectable characteristic response being detectable by external detection apparatus which is located outside the living body, said external detection apparatus being so adapted to convert said detectable characteristic response to an audible acoustic signal that is an audible representation of the changes in the difference in pressures on said two sides of said flexible diaphragm means;

(b) detecting said audible acoustic signal in order to detect variations in the difference in said two pressures on said flexible diaphragm means and;

(c) applying an external pressure on the skin above said implanted sensor with a controllable pressure source while detecting said audible audio signal, and varying said external pressure on the skin until said audible audio response indicates that said diaphragm means is at a stop position, at which point the value of said external pressure is in a known pressure relationship to said internal bodily pressure to be measured.

2. The method of claim 1 wherein said means having a detectable characteristic response comprises said flexible diaphragm means itself with said detectable characteristic response being the generation of acoustic pressure waves in the bodily media surrounding said pressure sensor when said flexible diaphragm means moves, and wherein said external detection apparatus is a stethoscope, said method further including the step of placing said stethoscope near the living body in which said pressure sensor is implanted in order to detect said acoustic pressure waves with said stethoscope.

3. The method of claim 1 wherein said means having a detectable characteristic response comprises an electronic circuit having an electronic response that is said characteristic response, said method further comprising the steps of detecting said electronic response by transmission of electromagnetic radiation between said pressure sensor and said detection apparatus and converting said electronic response into said audible acoustic signal, whereby the electronic response of said electronic circuit can be detected.

4. A method for measuring an in-vivo pressure, said method comprising the steps of:

(a) implanting in a living body a differential pressure sensor comprising;

(1) a flexible diaphragm means having a first and a second side, said differential pressure sensor being so adapted that when implanted beneath the skin in the living body said first side of said flexible diaphragm means is in mechanical pressure communication with a bodily medium the pressure of which is to be measured and said second side of said flexible diaphragm means is in mechanical pressure communication with an interior portion of the skin, so that changes in the difference in pressure on said two sides of said diaphragm will cause movement of said diaphragm means;

(2) stop means located within said sensor for stopping the movement of said diaphragm means, said stop means thereby defining a stop position of said diaphragm means when the pressure on said second side of said diaphragm means is in a known pressure relationship with respect to the pressure on the first side of said diaphragm means;

(3) means located within said sensor and at least in part cooperatively connected to said diaphragm means having a detectable characteristic response to movement of said diaphragm means;

(b) detecting by means of external detection apparatus located outside the living body, said detectable characteristic response and converting said response to an audible audio signal, whereby said audible audio signal provides an indication that said diaphragm means is at said stop position;

(c) applying an external pressure on the skin above said implanted sensor with a controllable pressure source while detecting said audible audio signal, and varying said external pressure until said audible audio response indicates that said diaphragm means is at said stop position, at which point the value of said external pressure is in said known pressure relationship to said internal bodily pressure to be measured.

5. The method of claim 4 wherein said means having a detectable characteristic response comprises said diaphragm means itself with said characteristic response being the generation of acoustic pressure waves in the bodily media surrounding said pressure sensor when said flexible diaphragm means moves, and wherein said external detection apparatus is adapted to detect said acoustic pressure waves and amplify them to produce audible acoustic signals, said flexible diaphragm means moving in a pulsatory motion and thereby producing pulsatory variations in said audible acoustic signals when the pressure sensor is implanted in the living body and the bodily pressure communicating with said first side of said flexible diaphragm means is pulsating with the cardiac pulsation rate, said method further comprising the step of detecting the point of diminution of the produced pulsatory acoustic signals as the external pressure is varied at which point said diaphragm means is at said stop position and the value of said external pressure is in said known relationship to said bodily pressure to be measured.

6. The method of claim 4 wherein said stop means and said flexible diaphragm means are so adapted that when said diaphragm means strikes said stop means at said stop position a sound wave is emitted with the emission of said sound wave being said characteristic response, and wherein said external detection apparatus is adapted to detect said sound wave and amplify it to an audible acoustic signal, and method further comprising the step of varying the externally applied pressure until said audible acoustic signal is detected and amplified to indicate that the diaphragm means has struck the stop means at which point the externally applied pressure is in said known relationship to said bodily pressure to be measured.

7. The method of claim 6 further comprising applying a variable pressure and a modulating pressure on the skin above the implanted sensor so that said variable pressure enables an average pressure to be communicated to said pressure sensor and to drive said flexible diaphragm means to said stop position while said modulating pressure modulates the movement of said flexible diaphragm means whereby when said flexible diaphragm means approaches said stop position said diaphragm means will strike said stop means in accordance with said modulated movement, and then varying the applied variable pressure until the audible acoustic signal indicates that the diaphragm means is striking said stop means in accordance with said modulating pressure, at which point the applied pressure is in said known pressure relationship to said bodily pressure to be measured.

8. The method of claim 6 wherein said external detection apparatus is a stethoscope, and further comprising the step of placing the stethoscope above the skin over the implanted sensor and listening for said sound wave.

9. The method of claim 4 wherein said means having a characteristic response is a resonant electronic circuit within said pressure sensor with said characteristic response being the resonant frequency of said electronic circuit, which changes with movement of the flexible diaphragm means, said method further comprising the steps of detecting said resonant frequency and converting the resonant frequency into an audible acoustic tone, the audio frequency of which is a function of said resonant frequency, and detecting the audio tone while varying said externally applied pressure until said audio tone ceases to vary with change of said externally applied pressure at which point said flexible diaphragm means has reached said stop position and the value of said externally applied pressure is in said known relation to said bodily pressure to be measured.

10. The method of claim 9 further comprising the steps of providing a reference audible signal having a reference audio tone and varying said acoustic tone so that the acoustic tone corresponding to said diaphragm means being in said stop position can be made equal to said reference audio tone, and varying said externally applied pressure until said acoustic tone equals said reference audio tone at which point the value of said externally applied pressure is in said known relation to said bodily pressure to be measured.